Amoxicillin-sulbactam (AMX-SUL) is an aminopenicillin/ss-lactamase inhibitor combination currently available in 29 countries and may be a suitable option for treating infections caused by Acinetobacter spp. Thus, we sought to search the optimal dosing strategy for this formulation through an ex vivo pharmacodynamic human model against Acinetobacter baumanniii. Four volunteers were randomized to...

Recent studies have shown that the currently circulating rubella viruses are mostly members of two genotypes, 1E and 2B. Also, genetically distinct viruses of genotype 1G have been found in East and West Africa. This study used a Mantel test to objectively include both genetic diversity and geographic location in the definition of lineages, and identified statistically justified lineages (n=13)...

for non-darcy flow in submerged porous media a one- dimensional mathematical model has been developed. rockfill detention dams are one of these porous media that comprised of relatively homogenous coarse rockfill which can be used to reduce flood discharge and hydrograph peak. in this research the focus was on the rockfill detention dams in submerged condition. the existence of overtopping rock...

PURPOSE Polymorphisms, such as a guanine inserted at position -1607 in the promoter region of human matrix metalloprotenase 1 (MMP-1) or a C-1562T substitution in the MMP-9 gene, have been shown to increase the transcriptional activity of these MMPs. The objective of this study was to investigate the possible relationship between these polymorphisms and early implant failure. MATERIALS AND ME...

This paper presents the experimental analysis that was conducted on small-scale 1g physical models of piled raft foundation structures with a group 2 × piles in loose sand. The purpose to reduce settlement raft. test program included twelve experiments, three which were alone and nine rafts at pile distances 3d, 4d, 5d lengths 10d, 20d, 40d, where d is diameter. results show current conventiona...

Fanconi anemia (FA) is a rare disorder characterized by physical abnormalities, bone marrow failure (BMF), increased risk of malignancies, and cellular hypersensitivity to DNA cross-linking agents. This study evaluated the genetic alterations in three major Fanconi genes (FANCA, FANCC, and FANCG) in 30 FA patients using multiplex ligation-dependent probe amplification and direct sequencing. Thi...

Voltage-gated calcium channels represent a heterogenous family of calcium-selective channels that can be distinguished by their molecular, electrophysiological, and pharmacological characteristics. We report here the molecular cloning and functional expression of three members of the low voltage-activated calcium channel family from rat brain (alpha(1G), alpha(1H), and alpha(1I)). Northern blot...

In this paper, the (2+1)-dimensional q-deformed Sinh-Gordon model has been investigated via (G?G,1G)-expansion and Sine-Gordon-expansion methods. These techniques successfully retrieve trigonometric as well hyperbolic solutions, along necessary restricted conditions applied on parameters. addition to these dark solitons complexiton solutions have also obtained. The proposed equation expands pos...

We study the electronic excitations near the charge-transfer gap in insulating CuO 2 planes, starting from a six-band model which includes p π and d xy orbitals and Cu-O nearest-neighbor repulsion U pd. While the low lying electronic excitations in the doped system are well described by a modified t−J model, the excitonic states of the insulator include hybrid d xy − p π states of A 2g symmetry...