Benzimidazole is one of the most important heterocyclic groups manifesting various biological properties, such as antibacterial, antifungal, antimicrobial, antiprotozoal and antihelmintic activities. Several benzimidazole derivatives are also active as inhibitors of type I DNA topoisomerases. In this study, three 1H-benzimidazole derivatives with different electronic characteristics at position...

New novel derivatives of N-((5-((6-oxido-6-(4 substituted phenoxy)-4,8-dihydro-1H-[1,3,2] dioxaphosphepino [5,6-c]pyrazol-1-yl) methyl)-1,3,4-thiadiazol-2-yl)carbamoyl) substituted benzene sulfo namides (7a-o as depicted in scheme) were Synthesized by condensation reaction of 4substituted Phenyl phosphorodichloridates (6a-c) and N-((5-((4,5-bis(hydroxymethyl)-1H-pyrazol-1-yi)methyl)1,3,4-thiadi...

Twelve new 4-(1H-indol-3-yl)-6-phenyl-1,2,3,4-tetrahydropyrimidin-2-ones/thiones (7-18) have been synthesized by reacting 1-aryl-3-(1H-indol-3-yl)-2-propen-1-one with urea and thiourea in ethanolic potassium hydroxide. Their structures have been confirmed by IR, 1H NMR and mass spectral data. The compounds were tested for their anti-inflammatory activity. Test results revealed that compounds sh...

About half of the drugs currently produced are chiral compounds, and about 90 % these compounds sold as racemates, consisting an equimolar mixture two enantiomers. Although they have same chemical structure, most optical isomers substances show marked differences in biological activity. It is known that presence a single asymmetric atom has become almost integral part advanced drug design. The ...

A series of Benzylidene-(2-{5, 6-substituted-1-[2-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]1H-benzoimidazol-2-yl}-phenyl-amine have been synthesized by 4'-{2-[2-(Benzylideneamino)-phenyl] 5, 6-substitutedbenzimidazol-1-yl}-biphenyl-2-carbonitrile.Preliminary screening of the title compounds for antihypertensive activity was performed. Only one of the compound was found to possess antihypertensive...