Two p-aminobenzoic acid-resistant mutants of the Madrid E strain of Rickettsia prowazekii, pr and prr have been described in previous publications (Weiss et al., 1957; 1959). It has been shown that certain properties, such as antigenic specificity, infectivity, and virulence for the chick embryo and cotton rat, have not changed in these strains. However, when the study was extended to susceptib...

Modafinil [2-[(diphenylmethyl)sulfinyl]acetamide] is used clinically in the treatment of narcolepsy and sleeping disorders. The synthesis of modafinil, begins with the reaction of benzhydrol and thioglycolic acid in trifluoroacetic acid to afford benzhydrylsulfinyl acetic acid. The reaction of acid with thionyl chloride in benzene followed by treatment with ammonium hydroxide gave acetamide...

The mechanism whereby sulfanilamide and its derivatives prevent bacterial growth is not known. None of the various theories advanced (1-3) has been conclusively substantiated by direct experimental proof. The most important recent contribution to the problem has been that of Woods (4), who demonstrated that p-aminobenzoic acid "blocks" the bacteriostatic effect of sulfanilamide in vitro. Follow...

Telah dilakukan kokristalisasi asam mefenamat (AM) dengan para-aminobenzoic acid (PABA) sebagai koformer menggunakan metode liquid‐assisted grinding. Penelitian ini bertujuan untuk mengetahui apakah dapat ditingkatkan laju disolusinya melalui pembentukan kokristal PABA. Kokristal AM-PABA dibuat perbandingan molar 1:2. Laju disolusi meningkat 1,45 kali lebih baik dibandingkan murni. Hasil karakt...

Microorganisms that require p-aminobenzoic acid or compounds of the folic acid group may have either requirement replaced by a purine and thymine (or thymidine) and several amino acids or vitamin B12 (Lampen et al., 1949; Stokstad, 1941; Baker et al., 1955); the vitamins, p-aminobenzoic or folic acids, are believed necessary for the synthesis of those compounds which can bypass them (Shive, 195...