The humanized monoclonal antibody trastuzumab is licensed for both the adjuvant treatment of early breast cancer and the palliation of metastatic breast cancer [1]. In the UK, trastuzumab is usually administered on a three weekly schedule. According to the license, it is infused over a period of 90 min and the patient is observed for 4.5 h after the loading dose, and for 30 min after all subseq...

DLS measures Brownian motion and relates this to the size of the particles. Brownian motion is the random movement of particles due to the bombardment by the solvent molecules that surround them. The larger the particle or molecule, the slower the Brownian motion will be. Smaller particles are "kicked" further by the solvent molecules and move more rapidly. An accurately known temperature is ne...

We studied the role of copper as a potential mediator of postischemic reperfusion injury in the isolated, perfused rat heart. Hearts were equilibrated with Krebs-Henseleit buffer for 10 minutes and then loaded with copper by way of perfusion with buffer containing 20 pM copper(II)-bis-histidial for 30 minutes. Control hearts were perfused with Krebs-Henseleit buffer alone during the loading per...

the spider mite, t. turkestani, is considered as one of the most important polyphagous pests of many crops. its reproductive ability, developmental time, preimaginal mortality and reproduction rate were determined on kidney bean at 20, 25 and 30°c,70±5% rh and 16l:8d. female longevity and immature developmental period (6.74 and 5.8 days, respectively) were shorter at 30°c than at 20 and 25°c. t...

Purpose: To evaluate the influence of commonly used eye drops on contrast sensitivity (CS). Design: Prospective study. Participants: One hundred twenty volunteers were enrolled. Methods: The CS of ophthalmologically healthy individuals was evaluated at baseline examination before the instillation, 20 and 40 minutes after the instillation of diclofenac sodium and commonly used anti-glaucoma eye ...