The Wnt pathway is a conserved signal transduction pathway that contributes to normal development and adult homeostasis, but is also misregulated in human diseases such as cancer. The tumor suppressor adenomatous polyposis coli (APC) is an essential negative regulator of Wnt signaling inactivated in.80% of colorectal cancers. APC participates in a multiprotein “destruction complex” that targets...

Psoriasis is a chronic inflammatory skin disease that develops under the influence of IL-23/T helper 17 cell axis and characterized by intense inflammation prominent epidermal hyperplasia. In this study, we demonstrate galectin-8, β-galactoside‒binding lectin, upregulated in epidermis human psoriatic lesions as well mouse model psoriasis induced intradermal IL-23 injections IL-17A‒treated kerat...

Psoriasis is a chronic skin disease associated with T helper (Th)17-mediated inflammation. Because CCR4 major chemokine receptor expressed on Th17 cells, we investigated the role of in modified imiquimod-induced psoriasis model that showed enhanced infiltration cells. CCR4-deficient mice had less severe than wild-type mice. cells were decreased lesions and regional lymph nodes In mice, CD44+ me...