Address correspondence to: Dr. Xin-Liang Ma Department of Medicine 1025 Walnut Street College Bldg. 808 Thomas Jefferson University Philadelphia, PA 19107 Tel: 215-955-4994 Fax: 215-503-4458 [email protected] Dr. Yajing Wang Department of Emergency Medicine 1025 Walnut Street College Bldg. 810 Thomas Jefferson University Philadelphia, PA 19107 Tel: 215-955-8895 Fax: 215-923-6225 Yajing.wang@...

Non-coding microRNAs (miRNAs), involved in post-transcriptional control, are widely involved in the mechanism of cellular resistance to antitumor chemotherapy. Ectopic expression of one of these miRNAs, miRNA‑215 (miR‑215), leads to chemoresistance by directly targeting dihydrofolate reductase (DHFR) and thymidylate synthase (TS), which are two of the most important targets of chemotherapeutic ...

The transcription factor caudal-type homeobox 1 (CDX1) is a key regulator of differentiation in the normal colon and in colorectal cancer (CRC). CDX1 activates the expression of enterocyte genes, but it is not clear how the concomitant silencing of stem cell genes is achieved. MicroRNAs (miRNAs) are important mediators of gene repression and have been implicated in tumor suppression and carcino...

The present study investigated the expression of microRNA (miR)-215 in non-small cell lung carcinoma (NSCLC) at tissue and cellular levels, as well as its biological functions and mechanism of action. A total of 56 patients with NSCLC were included in the present study. NSCLC tissues and tumor-adjacent normal tissues were resected and collected. Reverse transcription-quantitative polymerase cha...

In this study (1998-1999), we collected 215 macrolide-resistant Streptococcus pneumoniae isolates from an ongoing Canadian Respiratory Organism Surveillance Study involving 23 centers representing all regions of Canada. The prevalence of erythromycin-resistant S. pneumoniae was 8% (215 of 2,688). Of the 215 isolates, 48.8% (105 of 215) were PCR positive for mef(A) and 46.5% (100 of 215) were PC...

(a) What symmetries do these charges generate (i.e. how do the fields transform)? Show that they are symmetries of S. (b) If you want to, show that [Q, H] = 0, where H is the Hamiltonian. (c) Evaluate [Q, Q]. Hence, non-Abelian. (d) To complete the circle, find the Noether currents J i μ associated to the symmetry transformations you found in part 1a. (e) Generalize to the case of N scalar fields.

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that of their modern human contemporaries, they cared for their injured, and we have yet to last as long as a species on this planet as they did. However, modern humans went on to develop symbolic representation, complex social organisation, and also language in a way that was probably unmatched by the Neandertals. In the end, the nature of our speculations about what happened to the Neandertal...

Mesangial cell (MC) phenotypic transition is crucial for the progression of diabetic nephropathy. A major stimulus mediating high glucose-induced MC phenotypic transition is TGF-β1. Our current study focuses on microRNA-215 (miR-215) and investigates its role in TGF-β1-mediated MC phenotypic transition. Using real-time quantitative PCR (qRT-PCR) and northern blotting, we determined that the miR...