In the eight years since we last examined the amino acid exchanges seen in closely related proteins,' the information has doubled in quantity and comes from a much wider variety of protein types. The matrices derived from these data that describe the amino acid replacement probabilities between two sequences at various evolutionary distances are more accurate and the scoring matrix that is deri...

Neste trabalho é apresentada a co-imobilização de GOx e ferroceno numa matriz polimérica através de um método simples de uma etapa. Esse procedimento para a imobilização de ferroceno como mediador da reação enzimática não envolve a modificação do monômero ou da enzima, o que poderia levar à perda de sua atividade. A incorporação de ferroceno se traduz no incremento da sensibilidade, comparado a...

Complete trisomy 22, with or without mosaicism, has been reported as a distinct syndrome. In this report an infant is described who was externally male but with female rudimentary internal organs and whose karyotype was 47,XX+22.

2 Espaços Lineares (Vectoriais) 7 2.1 Subespaços lineares . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2.2 Vectores geradores . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2.3 Independência linear . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 2.4 Bases e dimensão de espaços lineares . . . ...

The synthesis and resolution of a class of chiral organic fluorophores, axially chiral 4,4-difluoro-4-bora-3a,4a-diaza-s-indacenes (Ax*-BODIPY), is described. Ax*-BODIPYs were prepared through a modular synthesis combined with a late stage Heck functionalisation. Resolution was achieved by preparative chiral HPLC. Absolute stereochemical assignment was performed by comparison of experimental EC...