The human sense of shape and pattern recognition can discern subtle nuances among groups of visual cues that no computer system can reproduce faithfully. Yet when it comes to measuring and evaluating chromatograms, analysts put a great deal of faith into their computerized data-handling systems. During the course of one year, a practising chromatographer might look at 10 000 or more peaks. Afte...

Pulmonary sparganosis mansoni is uncommon in general clinical practice, but prevalent in endemic foci. Pulmonary sparganosis mansoni shares some clinical and radiologic similarities that mimic other common pulmonary pathogens. Delayed diagnosis of pulmonary sparganosis mansoni can pose a significant hazard to the patient. Indeed, a history of ingesting uncooked stone cracks in endemic areas is ...

Currently, there are difficulties associated with the culturing of pluripotent human embryonic stem cells (hESCs), and knowledge regarding their regulatory mechanisms is limited. MicroRNAs (miRNAs) regulate gene expression and have critical functions in stem cell self-renewal and differentiation. Moreover, fibroblast growth factor (FGF) and the insulin-like growth factor receptor (IGF-1R) are k...

BACKGROUND Kawasaki disease (KD) is now the most common cause of acquired cardiac disease in children due to permanent coronary artery damage with unknown etiology. The study sought to determine the role of blood microRNA miR-223 in KD and KD-induced injuries in vascular endothelial cells (ECs) as well as the mechanisms involved. METHODS AND RESULTS MicroRNA profiles in serum from patients wi...

The notion of ‘integration’ in the context of health information systems is ill-defi ned yet in widespread use. We identify a variety of meanings ranging from the purely technical integration of information systems to the integration of services. This ambiguity (or interpretive fl exibility), we argue, is inherent rather than accidental: it is a necessary prerequisite for mobilizing political a...

In the last few years, the treatment of castration-resistant prostate carcinoma (CRPC) has changed completely. The approval of docetaxel and subsequent investigation in this field have led to development of new agents that have demonstrated an improvement in overall survival in the post-docetaxel setting, such as cabazitaxel and abiraterone. Radium-223 chloride is a radioisotope that has recent...

The aim of this study was to evaluate macrophages repolarization from pro-inflammatory M1 to anti-inflammatory M2 phenotype upon transfection with microRNA-223 (miR-223) duplexes and miR-223 expressing plasmid DNA encapsulated in CD44-targeting hyaluronic acid-poly(ethyleneimine) (HA-PEI) nanoparticles (NPs). The HA-PEI/miR-223 NPs with spherical shape and an average diameter of 200 nm were eff...

In previous analyses of the 1988 National Maternal and Infant Health Survey (NMIHS) and the 1988 National Survey of Family Growth (NSFG), we found that after differences in demographic and socioeconomic characteristics were taken into account, mothers who had intended to conceive were more likely than those who had not to recognize their pregnancy within the first six weeks and to initiate pren...

Platelets play a significant role in atherosclerosis, stroke, and asthma through active interaction with neutrophils, monocytes, and vascular endothelial cells. The mechanism underlying these intercellular interactions, however, is incompletely understood. In this study, we report that platelets can remotely modulate vascular endothelial cell apoptosis through releasing microRNA-223 (miR-223)-c...

A 76-year-old man with symptomatic bone metastases from castration-resistant prostate cancer underwent Radium-223-dichloride (Ra-223) therapy. Before Ra-223 therapy, he had normal peripheral blood cell counts. Ra-223 therapy relieved his shoulder and low back pain. The elevation of the serum prostate-specific antigen (PSA), doubling every month during Ra-223 therapy, suggested a PSA flare or re...