As a common anticancer drug, cisplatin has been widely used for treating tumors in the clinic. However, its side effects, especially its nephrotoxicity, noticeably restrict the application of cisplatin. Therefore, it is imperative to investigate the mechanism of renal injury and explore the corresponding remedies. In this study, we showed the phenotypes of the renal tubules and epithelial cell ...

Background: Use of ultra-high diluted remedies in homeopathy and their claimed efficacy curing diseases has been challenged time again by non-believers despite many evidence-based positive results published favor curing/ameliorating disease symptoms. Aims: To test the ability homeopathic beyond Avogadro’s limit, if any, manifesting gene modulating effects controlled vitro experimental model. ...

BACKGROUND Vascular calcification resembles bone formation and involves vascular smooth muscle cell (SMC) transition to an osteoblast-like phenotype to express Runx2, a master osteoblast transcription factor. One possible mechanism by which Runx2 protein expression is induced is downregulation of inhibitory microRNAs (miR). METHODS AND RESULTS Human coronary artery SMCs (CASMCs) treated with ...

Cyclophosphamide is a widely used antitumor drug, with induced adverse effects, such as intestinal mucosal injury and immunosuppression. Norcantharidin possesses anticancer activity through enhancement of immunity. We investigated the role norcantharidin in cyclophosphamide-induced Mice were treated cyclophosphamide, exposed to norcantharidin. Enzyme-linked-immunosorbent serologic assay was per...

Glass/Nb2O5 and Nb/Nb2O5 electrodes were prepared by electrodeposition and used as anodes for electrochemical degradation of chlorpyrifos (CPF) in aqueous solution. Different operating conditions and factors affecting the treatment process including current density, temperature, initial concentration of chlorpyrifos, pH, conductive electrolyte and time of electrolysis were studied and optimized...

OBJECTIVES Whether the ultra-highly-diluted remedies used in homeopathy can effectively bring about modulations of gene expressions through acetylation/deacetylation of histones has not been explored. Therefore, in this study, we pointedly checked if the homeopathically-diluted anti-cancer remedy Condurango 30C (ethanolic extract of Gonolobus condurango diluted 10(-60) times) was capable of arr...

ER stress PERKs up an miRNA B yrd et al. describe how a microRNA (miRNA) fi ne-tunes a cell's response to ER stress. When stressful conditions disrupt the ER's normal function, the cell activates an unfolded protein response (UPR) that restores the organelle's ability to fold and export proteins to the secretory pathway. The transcription factor XBP1 is a key component of the UPR that boosts ER...

Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Abstract Inactivation of the von-Hippel Lindau (VHL) tumor suppressor gene occurs in 90% of human clear cell renal cell carcinomas (ccRCC), and leads to the stable expression of the hypoxia inducible factors HIF1Į and HIF2Į. The constitutive expression of HIF1Į in a majority of VHL-deficient tu...

The most commonly encountered cyanobacterial toxins in freshwater are microcystins. Microcystins are extremely stable and resistant to chemical hydrolysis or oxidation and can cause illness or death in animals and humans. In this study, a total of 15 bacterial strains were isolated and screened for microcystin degradative activity from Kaen Nakhon Lake, Khon Kaen Province, Thailand. Among these...

Lead (II) ion adsorption capacity of clinoptilolite from artificial polluted tap water was investigate in this study. For the experimental studies, Clinoptilolite mineral which is 25-140 mesh size was used by activating with HCl, and lead ion removal efficiencies were examined. Experiments were studied under laboratory batch conditions were run at different pH values, temperatures. The highest ...