In this study, the antiulcerogenic effect of essential oil from Baccharis dracunculifolia was evaluated using the model of acute gastric lesions induced by ethanol. The ulcerative lesion index (ULI) was significantly reduced by oral administration of the essential oil of B. dracunculifolia at doses of 50, 250 and 500 mg/kg which reduced the lesions by 42.79, 45.70 and 61.61%, respectively. The ...

The atherosclerotic effect of Methanolic extract of Cleome viscosa was studied in Streptozotocin induced Diabetic Rats fed with Atherogenic Diet [1.5 ml olive oil containing 8 mg of vitamin D-2 and 40 mg cholesterol] for 5 consecutive days. Oral administration of extract to diabetic rats [250 mg/kg and 500 mg/kg for 30 days] produced significant (p<0.01) fall in fasting blood glucose levels in ...

sugar beet (beta vulgaris) is one of the hosts for different root-knot nematode species. in this study, firstly the effect of different inoculum levels including 250+250, 500, 500+250, 750, 500+500 and 1000 second stage juveniles of meloidogyne javanica were evaluated on a susceptible variety named jolgeh. the results showed that all inoculum levels were suitable for infection on sugar beet pla...

NO acting through soluble guanylyl cyclase and cGMP formation is a negative regulator of cardiomyocyte hypertrophy. Downstream targets mediating the inhibitory effects of NO/cGMP on cardiomyocyte hypertrophy have not been elucidated. In addition to its antihypertrophic effects, NO promotes apoptosis in cardiomyocytes, presumably through cGMP-independent pathways. We investigated the role of cGM...

OBJECTIVES Tetrasodium pyrophosphate (TSP) is used in processed meat products, as an emulsifier in cheese, and as a color preservative in soybean paste. However, little is known about its toxicity. This study was conducted to investigate the potential acute and repeated dose toxicity of TSP in Spraque Dawley (SD) rats. METHODS In the acute study, animals were administered with oral or dermal ...

In the present study, the analgesic and anti-inflammatory activity of 95% ethanolic extract of Woodfordia fruticosa (WFE) flowers in acute, subacute and chronic models of inflammation was assessed in rats and mice. Oral administration of WFE (250 and 500 mg/kg) exhibited significant anti-inflammatory activity in acute (carrageenin and autocoids induced hind paw edema), subcute (formaldehyde-ind...

Vitamin E (alpha-gamma-tocopherol) is an important component in biological membranes. A decrease in its concentration imposes structural and functional damage to the cells. The object of this study was to assess the effect of a graded dietary vitamin E (E) intake on E concentration in specific regions of the brain, and its influence on vitamin C levels and neurological function. Following a 2-m...

BACKGROUND An elevated plasma total homocysteine concentration is a risk factor for cardiovascular disease and neural tube defects. A high daily intake of supplemental folic acid is known to decrease total homocysteine concentrations. OBJECTIVE We studied the effect of low-dose folic acid administration (250 or 500 (microgram/d) for 4 wk on plasma total homocysteine concentrations and folate ...

BACKGROUND Despite advances with new therapies, a significant proportion of patients (>30%) suffer delayed-onset chemotherapy-induced nausea and vomiting (CINV) despite use of antiemetics. APF530 is a sustained-release subcutaneous (SC) formulation of granisetron for preventing CINV. APF530 pharmacokinetics, safety, and efficacy were studied in two open-label, single-dose Phase II trials (C2005...