Metastatic melanoma is an aggressive cancer with very low response rate against conventional chemotherapeutic agents such as dacarbazine (DTIC). Inhibitor of Rb–Raf-1 interaction RRD-251 was tested against the melanoma cell lines SK-MEL-28, SK-MEL-5, and SK-MEL-2. RRD-251 was found to be a potent inhibitor of melanoma cell proliferation, irrespective of V600E B-Raf mutation status of the cell l...

Moral text processing was used as an ecologically valid method for assessing implicit and explicit moral understanding and development. The authors tested undergraduates, seminarians, and graduate students in political science and philosophy for recall of moral narratives and moral expository texts. Multivariate analyses of covariance using educational experience as an independent variable, age...

Thomas Suddendorf is Professor of Psychology at the University of Queensland, Australia. He was born and raised in Germany, but has spent most of his adult life in the Antipodes. He studies the development of mental capacities in young children and in nonhuman animals to answer fundamental questions about the nature and evolution of the human mind. He has received honors and distinctions for bo...

All-trans-retinoic acid (RA) is known to induce terminal granulocytic differentiation and cell cycle arrest of HL-60 cells. Responding to an RA-induced cytosolic signaling machine, c-Raf translocates to the nucleus, providing propulsion for RA-induced differentiation. This novel mechanism is not understood, but presumably reflects c-Raf binding with nuclear gene regulatory proteins. RRD-251 is ...

Introduction:  IL-8 is one of the pro-inflammatory cytokines which can play an essential role in the pathogenesis of chronic rhinosinusitis (CRS) as well as nasal polyposis (NP). The ability of individuals in producing IL-8 is partially determined by IL-8-251 A/T polymorphism. Hence, the aim of the present study was to investigate the association between IL-8-251 A/T and CXCR2 +1208 C/T genes ...

CONTENTS INTRODUCTION 237 TRANSFERS INVOLVING EUKARYOTES 239 Phylogenetic Congruency Test 239 Pitfalls Involving Paralogies 241 Pitfalls Involving Unequal Razes 242 Convergent Replacements 243 Tests of Significance 244 MOBILE GENETIC ELEMENTS 244 CHROMOSOMAL GENES IN BACTERIA 245 Mosaic Nature of the E. coli chromosome 245 Salmonella and the Criteria of GC Content 247 Codon Bias 249 Other Bacte...

Why Is a Representationalist Analysis Useful? In this chapter I will briefly sketch the outline of a representationalist theory of subjective experience. (See also Metzinger 1993, forthcoming). A representationalist theory is one that chooses to analyze its target properties – those aspects of the domain which eventually are to be explained – on a certain level of description: by describing con...

THE Queen's University received a benefaction from Mrs. Carnwath and her family in 1955 to provide prizes in social and preventive medicine in memory of her husband, the late Dr. Thomas Carnwath. These awards originally took the form of a medal and book prize for the student gaining the highest place in the final part one examination in social and preventive medicine, a book prize for the stude...

T Sydenham is undoubtedly the most celebrated British physician. He has been considered the father of English medicine and the English equivalent of Hippocrates.1 Sydenham was born on September 1624 in Wynford Eagle, Dorset. He joined Magdalene Hall, Oxford at the age of e ighteen to study m e d i c i n e . H o w e v e r there was an interruption in his studies because o f h i s p a r t i c i p...