The authors investigated the effect of the opioid antagonist naloxone on wheel-running behavior in Balb/c mice. Naloxone delayed the acquisition of wheel-running behavior, but did not reduce the expression of this behavior once acquired. Delayed acquisition was not likely a result of reduced locomotor activity, as naloxone-treated mice did not exhibit reduced wheel running after the behavior wa...

Agency for Healthcare Research and Quality shows dramatic increases in outpatient complete mastectomies in five States. In Colorado, for instance, outpatient complete mastectomies jumped from under 1 percent in 1990 to 22 percent in 1996. Claudia Steiner, M.D., M.P.H., of AHRQ’s Center for Organization and Delivery Studies, and her colleagues Caroline Case, M.D., of Georgetown University, and M...

The generalized conceptual model for a fractured bedrock aquifer consists of low-permeability matrix blocks separated by highly permeable fractures that act as preferential pathways for ground water flow. The National Research Council (NRC 1996) summarizes three approaches for simulating ground water flow in fractured aquifers. The most common approach is to represent the system with an equival...

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 577 1. Epidemiology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 578 1.1 Elderly in Long-Term Care Facilities . . . . . . . ...

Scientific Noltes and News ..583 University and Educational Notes .......................... 587 Disewsion and Correspondence: Tryparsamide: PROFESSOR A. S. LOEVENHART. Is an International List of Genera of Cultivated Plants Possible? DR. ALFRED GUNDERSEN. Note on the Geographical Distribution of the Protozoan Genus Cryptochiluim Maupas: PROFESSOR A. W. L. BRAY. The Losses in Trout Fry after Di...

AIM To explore the sensitivity of bacteria commonly found in root canals to 254 nm ultraviolet (UV) light, either as individual cells or as participants of a bacterial multilayer. METHODOLOGY The sensitivity of oral bacteria, as individual cells, to UV light was tested by subjecting plates streaked with bacteria to 254 nm UV, at a fluence of 1-20 mJ cm(-2). An experimental model was designed ...

BACKGROUND The characteristic clinical heterogeneity and mostly slow-growing behavior of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) cause problems in finding appropriate treatments. Thus, the current therapy options are not satisfactory. PKI-587 is a highly potent, novel dual inhibitor of PI3K and mTORC1/C2. AIM We assessed the effects of PKI-587 in different GEP-NEN tumor mod...