نتایج جستجو برای: 2h phthalazin 1 one
تعداد نتایج: 4200849 فیلتر نتایج به سال:
MRTX1719 was identified as a potent inhibitor of the PRMT5/MTA complex, designed to selectively target MTAP-deleted cancers. A scalable synthesis this atropisomeric compound and an efficient isolation desired isomer were required support Phase 1 clinical trials, established through further development racemic medicinal chemistry route. In key step, (M)-atropisomer amplified from API by combinin...
The title compound, C(15)H(11)NO, consists of a planar isoquinolinone group to which a phenyl ring is attached in a twisted fashion [dihedral angle = 39.44 (4)°]. The crystal packing is dominated by inter-molecular N-H⋯O and C-H⋯O hydrogen bonds which define centrosymmetric dimeric entitities.
Sulfonated magnetic nanoparticles (SO3H-Fe3O4@SiO2 MNPs) have been explored as an efficient, cost-effective, and recyclable nanocatalyst for the facile synthesis of 3,4-dihydro-2H-indazolo[1,2-b]phthalazin-1,6,11(13H)-triones through a one-pot three-component reaction between aldehydes, dimedone, and phthalhydrazide under mild and green (solvent-f...
Twenty-five polysubstituted phthalazinone derivatives were synthesized and tested for their antifungal activity against a panel of pathogenic and clinically important yeasts and filamentous fungi. Among them, the compound 4-(4-chlorobenzyl)-2-methylphthalazin-1(2H)-one (5) exhibited a remarkable antifungal activity against standardised strains of dermatophytes and Cryptococcus neoformans, as we...
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