To solve the problem of delivering pharmacologically promising 3ʹ,5ʹ-cyclic diadenosine monophosphate (cyclo-diAMP) to target cells in humans and animals, complexes above-mentioned dinucleotide with natural polymer – chitosan were originally synthesized by ionotropic gelation technique. It was found that binding degree cyclo-diAMP this biopolymeric carrier reaches 60 %; wherein capacity obtaine...

OBJECTIVES The Epworth sleepiness scale (ESS) is often used for screening of sleep apnea syndrome (SAS) in the workplace. We conducted pulse oximetry for workers of a large transportation company, who were selected based on their response to a questionnaire that included ESS and breathing pattern during sleep. METHODS Pulse oximetry was performed for 803 of 3,761 male workers. A 3% oxygen des...

STUDY DESIGN The Oswestry Disability Index (ODI) has become one of the principal condition-specific outcome measures used in the management of spinal disorders. This review is based on publications using the ODI identified from the authors' personal databases, the Science Citation Index, and hand searches of Spine and current textbooks of spinal disorders. OBJECTIVES To review the versions of...

Abstract Background Oswestry Disability Index (ODI) is broadly used in clinical and research settings for assessing the disability level patients with lumbar radiculopathy but it has not been translated into Urdu language according to pre-established translation guidelines as well validity reliability of ODI version tested yet. The aim this study was translate native (ODI-U) recommended measure...

STUDY OBJECTIVES It has been suggested that sleep-disordered breathing (SDB) is a risk factor for ischemic heart disease, and may be associated with increased morbidity and mortality due to cardiovascular disease. The aim of this study was to examine the relation between nocturnal oxygen desaturation (NOD) due to SDB and the Gensini score, which is given to define the severity of coronary ather...

Cloning, expression and purification The gene coding for the SP lyase from Geobacillus thermodenitrificans (GTNG_2348) and the C140A mutant were cloned in our previous study. [1] The C140A/S76C mutant for this study was generated by site-directed mutagenesis (by QuickChange PCR mutagenesis) using the pET-M11-C140A mutant vector as template and the following primers with the modified bases indic...

Pulse oximetry is useful for screening sleep apnoea syndrome in dialysis patients Sir, Sleep apnoea syndrome (SAS) is characterized by repetitive nocturnal hypoxia, while it is also known to be a risk factor for cardiovascular disease [1]. The prevalence of SAS in dialysis patients has been shown to range from 20 to 50% in comparison to a range of 2–4% in the general population [2,3]. Although ...

BACKGROUND CONTEXT The nerve root sedimentation sign in transverse magnetic resonance imaging has been shown to discriminate well between selected patients with and without lumbar spinal stenosis (LSS), but the performance of this new test, when used in a broader patient population, is not yet known. PURPOSE To evaluate the clinical performance of the nerve root sedimentation sign in detectin...

Introduction When obstructive sleep apnoea (OSA) does not occur throughout sleep, there must be factors influencing its presence or absence. These are most likely to be sleep stage, posture and presleep alcohol, among others. We hypothesised that as OSA severity increases, the likelihood of postural OSA (POSA) would also decrease. Methods Laboratory sleep studies of 39 patients with OSA were ...