We have previously reported that rats are resilient to the hepatotoxic and lethal combination of chlordecone (CD) and carbon tetrachloride (CCl4) during early postnatal development. The overall findings pointed to stimulated cell division and tissue repair mechanisms as the underlying cause of resistance. The objective of the current study was to investigate if the antimitotic effect of colchic...

the effects of different concentrations of the hydroalcoholic extract of dried powdered leaves of cichorium intybus l., on ccl4-induced hepatotoxicity in vivo in rats and ccl4-induced cytotoxicity in isolated rat hepatocytes were investigated. rats received different concentrations of the extract by i.p. injection for 3 consecutive days before the injection of (3ml/kg) ccl4 (i.p.). twenty four ...

There is some anecdotal evidence that oxygen-ozone therapy may be beneficial in some human diseases. However so far only a few biochemical and pharmacodynamic mechanisms have been elucidated. On the basis of preliminary data we postulated that controlled ozone administration would promote an oxidative preconditioning preventing the hepatocellular damage mediated by free radicals. Six groups of ...

A toxic organic substance CCl4 is a well known model compound for studying detoxification function of the liver and developing oxidative stress. The goal study was to estimate effect L-glutamic acid (L-Glu) N-acetylcysteine (NAC) administration on rat blood parameters upon effects CCl4. Experimental male Wistar rats were injected intraperitoneally with CCl4, CCl4/L‑Glu group additionally L-Glu ...

in india, a number of medicinal plants and their formulations are used to cure hepatic disorders in traditional systems of medicine. no systemic study has been done on protective effect of cucumis trigonus roxb. (cucurbitaceae) to treat hepatic diseases. protective action of c. trigonus fruit extracts was evaluated in this study in animal model of hepatotoxicity, which was induced by carbon tet...

The effects of Silymarin on growth performance, internal organs, and some blood parameters were investigated in Japanese quail that were subjected to oxidative stress induced by carbon tetrachloride (CCl4). An experiment was conducted as a completely randomized design in a factorial arrangement (2 × 2) with four replicates of 30 birds each. Factors included two levels of Silymarin (0 and 1 mL/k...

Objectives. The purpose of the study is to evaluate the hepatoprotective effect of rutin in carbon tetrachloride- (CCl4-) induced liver injuries in rat model. Methods. Forty male Wistar albino rats were divided into four groups. Group I was the control group and received dimethyl sulphoxide (DMSO) and olive oil. Group II received rutin. Groups III was treated with CCl4. Group IV was administere...

p-Dimethvlaminoazobenzene (D.A.B.) was fed to rats for periods of 4 to 24 weeks. The treatment was followed by repeated injections of carbon tetra chloride (CCl4). The groups thus treated were compared with groups which were fed on basal diet after D.A.B. was discontinued . 1) CCl4 was found to act as a promoting factor and to accelerate the carcinogenic process of D.A.B. 2) In comparison with ...

Objective: This study was designed to examine the potential protective effects of Rheum ribes L., and quercetin on protein carbonyl (PCO) in kidney liver tissue, trace elements (Fe, Cu, Zn) mineral (P) serum samples Wistar rats carbon tetrachloride (CCl4)-induced oxidative damage. 
 Methods: The 2, 4-dinitrophenylhydrazine (DNPH) method is most reliable widely used measure levels proteins....