When several treatments are available for evaluation in a clinical trial, different design options are available. We compare multi-arm multi-stage with factorial designs, and in particular, we will consider a 2 × 2 factorial design, where groups of patients will either take treatments A, B, both or neither. We investigate the performance and characteristics of both types of designs under differ...

The aim of this study is to prepare fluvastatin nanostructured lipid carriers (FLV-NLCs) in order to find an innovative way to alleviate FLV-associated disadvantages. The limitations include poor solubility and extensive first-pass metabolism, resulting in low (30%) bioavailability and short elimination half-life (1-3 hours). FLV-NLCs were prepared by hot emulsification-ultrasonication method. ...

We give a combinatorial interpretation for the super Catalan number S(m,m + s) for s ≤ 3 using lattice paths and make an attempt at a combinatorial interpretation for s = 4. We also examine the integrality of some factorial ratios.

The effect of the Transcendental Meditation (TM) technique on working memory and field independence was investigated in a twelve-week longitudinal time-series study in which the uMatch Me" computerized memory game and the Rod and Frame Test were administered daily to a matched pair of 11-year-old boys and a matched pair of 14-year-old girls. One of the boys and one of the girls began the TM tec...

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the objective of this work was to develop bioadhesive topical gel of aceclofenac with the help of response-surface approach. experiments were performed according to a 3-level factorial design to evaluate the effects of two independent variables [amount of poloxamer 407 (pl-407 = x1) and hydroxypropylmethyl cellulose k100 m (hpmc = x2)] on the bioadhesive character of gel, rheological property o...