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http://www.sciencemag.org/cgi/content/full/322/5906/1387 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/322/5906/1387/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http:/...
PURPOSE To determine the maximum tolerated dose (MTD), safety, pharmacokinetics, pharmacodynamics, immunogenicity, and preliminary antitumor activity of CT-322 (BMS-844203), a VEGFR-2 inhibitor and the first human fibronectin domain-based targeted biologic (Adnectin) to enter clinical studies. EXPERIMENTAL DESIGN Patients with advanced solid malignancies were treated with escalating doses of ...
OBJECTIVE We aimed to explore the association of P16, MGMT and HMLH1 with gastric cancer and their relation with Methylenetetrahydrofolate reductase (MTHFR). METHODS 322 gastric patients who were confirmed with pathological diagnosis were included in our study. Aberrant DNA methylation of P16, MGMT and HMLH1 and polymorphisms of MTHFR C677T and A1298C were detected using PCR-RFLP. RESULTS T...
Correspondence R. Krysiak Department of Internal Medicine and Clinical Pharmacology Medical University of Silesia Medyków 18 40-752 Katowice Poland Tel.: + 48/322/523 902 Fax: + 48/322/523 902 [email protected]
We report on the formation and evolution of two large-scale, synchrotron-emitting jets from the black hole candidate H 1743−322 following its reactivation in 2003. In November 2003 after the end of its 2003 outburst, we noticed, in observations with the Australia Telescope Compact Array, the presence of a new and variable radio source about 4.6 ′′ to the East of H 1743−322, that was later found...
There is growing evidence that microRNAs play important roles in cellular responses to hypoxia and in pulmonary hypertensive vascular remodeling, but the exact molecular mechanisms involved are not fully elucidated. In this study, we identified miR-322 as one of the microRNAs induced in lungs of chronically hypoxic mice and rats. The expression of miR-322 was also upregulated in primary culture...
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