In eukaryotes many players in the DNA-damage response (DDR) catalyze protein sumoylation or ubiquitylation. Emphasis has been placed on how these modifications orchestrate the sequential recruitment of repair factors to sites of DNA damage or stalled replication forks. Here, we shed light on a pathway in which sumoylated factors are eliminated through the coupled action of Sumo-targeted ubiquit...

Affibody molecules are small (7 kDa), non-immunoglobulin scaffold proteins with a potential as targeting agents for radionuclide imaging of cancer. However, high renal re-absorption of Affibody molecules prevents their use for radionuclide therapy with residualizing radiometals. We hypothesized that the use of Affibody-based peptide nucleic acid (PNA)-mediated pretargeting would enable higher a...

Estrogen receptor-α (ERα) is essential for estrogen-dependent growth and its level of expression is a crucial determinant of response to endocrine therapy and prognosis in ERα-positive breast cancer. Breast cancer patients show a wide range of ERα expression levels which change in individual patients during disease progression and in response to systemic therapies. However, little is known conc...

Conceptualization of Gastrointestinal Illness 337 Biomedical Model 337 Biopsychosocial Model 338 Early Life 339 Early Learning 339 Culture and Family 340 Psychosocial Environment 340 Life Stress and Abuse 341 Psychological Factors 341 Coping and Social Support 342 Brain-Gut Axis 342 Stress and Gastrointestinal Function 342 Role of Neurotransmitters 343 Regulation of Visceral Pain 343 Effects of...

ablation [54]. abstraction [116, 133]. accelerated [402]. acceleration [22]. accelerometers [274]. accessibility [443]. account [50]. Accurate [51]. achieving [326]. ACM [175]. acoustic [79]. acquisition [391]. actions [137]. active [145]. adaptation [214, 203, 227]. Adaptive [59, 319, 367, 428, 209, 371, 384, 300, 396, 69, 305]. Adding [235]. adjustment [300, 323]. advances [162]. Advected [28...

miRNAs have been shown to play pivotal roles in the establishment and progression of colon cancer, but their underlying mechanisms are not fully understood. N-acetyltransferase NAA10 participates in many cellular processes, including tumorigenesis. Here we showed that miR-342-5p and miR-608 suppressed the tumorigenesis of colon cancer cells in vitro and in vivo by targeting NAA10 mRNA for degra...

, 1182 (2013); 342 Science Martti Kauranen Freeing Nonlinear Optics from Phase Matching This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portio...