Ultra-low-dose opioid antagonists enhance opioid analgesia and reduce analgesic tolerance and dependence by preventing a G protein coupling switch (Gi/o to Gs) by the mu opioid receptor (MOR), although the binding site of such ultra-low-dose opioid antagonists was previously unknown. Here we show that with approximately 200-fold higher affinity than for the mu opioid receptor, naloxone binds a ...

Raman spectra have been measured for intact rat lens nuclei at various stages of aging in an attempt to gain further insight into age-related structural changes in the lens proteins, especially changes concerning protein sulfhydryl groups. Two Raman bands at 2579 and 2561 cm-1 were observed to be assignable to SH stretching modes of the cysteine residues. These bands have been attributed to "ex...

www.ethnobotanyjournal.org/vol10/i1547-3465-10-305.pdf Ethnobotany Research & Applications 10:305-320 (2012) Girmay Zenebe, Hawassa University, Wondo Genet College of Forestry and Natural Resources, School of Forestry, P. O. Box 128, Shahemene, ETHIOPIA. [email protected] Mohammed Zerihun, Forum for Social Studies, Addis Ababa, ETHIOPIA. [email protected] Zewdie Solomon, Hawassa Un...

4 Running title: Synechocystis serine protease HhoA 5 6 Pitter F. Huesgen, Philipp Scholz and Iwona Adamska* 7 8 Department of Physiology and Plant Biochemistry, University of Konstanz, 9 Universitätsstrasse 10, D-78457 Konstanz, Germany 10 11 12 13 14 15 16 17 18 * Corresponding author. Mailing address: Department of Physiology and Plant 19 Biochemistry, University of Konstanz, Universitätsstr...

Sugar cane bagasse was crosslinked with epichlorohydrin in the presence of NH4OH or imidazole. The obtained water-insoluble products were characterized in terms of yield, anion-exchange capacity, packed volume, and dye-binding properties. Yields were highest using a 3 : 1 epichlorohydrin to NH4OH molar ratio, producing weak anion exchangers. The weak anion exchangers had low dye-binding capacit...

4 Running title: Synechocystis serine protease HhoA 5 6 Pitter F. Huesgen, Philipp Scholz and Iwona Adamska* 7 8 Department of Physiology and Plant Biochemistry, University of Konstanz, 9 Universitätsstrasse 10, D-78457 Konstanz, Germany 10 11 12 13 14 15 16 17 18 * Corresponding author. Mailing address: Department of Physiology and Plant 19 Biochemistry, University of Konstanz, Universitätsstr...

A numerical study on the dynamic responses of irregular fibers under axial tension is presented in this article. The irregularity was represented by a sinusoidal shape profile along the fiber axis. The finite element method was used in the simulations and the maximum first principal stress due to the dynamic pulling has been examined. Our numerical results indicate that the first principal stre...

Recent genomic studies have outlined a landscape of recurrent alterations within some subtypes of lymphoid cancer. Yet, the timing and cellular contexts during which these alterations occur (ie, the molecular ontogeny) remain poorly understood. Lymphoid malignancies offer an exceptional opportunity to delineate the ontogeny of somatic alterations, as lymphocyte differentiation absolutely requir...