Hepatocellular carcinoma (HCC) is currently ranked as the third leading cause of cancer-related mortality worldwide. microRNAs (miRs) serve important roles in the development and progression of HCC. miR-365 has been demonstrated to function as a tumor suppressor in several types of cancer, including HCC; however, the mechanisms by which miR-365 regulates HCC apoptosis remains to be elucidated. ...

Artikkelen kaster lys over språkhistoria til en av Norges nasjonale minoriteter, jødene, som etablerte seg i siste halvdel 1800-tallet. Også tidligere spor jødisk nærvær på norsk jord blir omtalt, men hovedvekta ligger perioden 1880–1940. Med utgangspunkt lang rekke skriftlige kilder kartlegges noen de språklige praksisene kjennetegnet jødiske miljøene dette tidsrommet. Et sentralt motiv er spr...

MicroRNAs (miRNAs) have important roles in the initiation and progression of human cancer, including breast cancer. We evaluated miR‑365 expression in breast cancer tissues, and investigated its effects on cell growth, cell cycle, cell invasion, and expression of its target gene ADAMTS-1. miR‑365 expression levels were analyzed in breast cancer tissues and adjacent normal tissues using qRT-PCR....

Finite and Infinite Sets. Countability. Proof Techniques (Chapter 1, Sections 1.4, 1.5) Finite sets finite number of elements can be counted Infinite sets infinite number of elements Equinumerous sets: Sets A and B are equinumerous if there is a bijection f : A → B E.G.: A = {1,2,3}, B = {a,b,c} Countably infinite sets: A set is countably infinite if it is equinumerous with N (the set of natura...

MircroRNA functions as tumor suppressor or promoter in hepatocellular carcinoma (HCC). Researchers have found that miR-365 expression was lower in HCC tissues compared with that in adjacent normal tissues. However, its prognostic significance and anti-proliferation effect in HCC remain to be clarified. In this study, we firstly found that miR-365 expression was lower in HCC tissues compared wit...

Morphine tolerance is a challenging clinical problem that limits its clinical application in pain treatment. Non-coding microRNAs (miRNAs) modulate gene expression in a post transcriptional manner, and their dysregulation causes various diseases. However, the significance of miRNAs in morphine tolerance is still poorly understood. In the present study, we hypothesized that microRNA-365 (miR-365...

Glucocorticoid administration is the leading cause of secondary osteoporosis. In this study, we tested the hypotheses that histone deacetylase 4 (HDAC4) is associated with glucocorticoid-induced bone loss and that HDAC4 dependent bone loss can be ameliorated by miRNA-365. Our previous studies showed that miR-365 mediates mechanical stimulation of chondrocyte proliferation and differentiation by...

Mechanical stress plays an important role in the initiation and progression of osteoarthritis. Studies show that excessive mechanical stress can directly damage the cartilage extracellular matrix and shift the balance in chondrocytes to favor catabolic activity over anabolism. However, the underlying mechanism remains unknown. MicroRNAs (miRNAs) are emerging as important regulators in osteoarth...