For vocal animals, recognizing species-specific vocalizations is important for survival and social interactions. In humans, a voice region has been identified that is sensitive to human voices and vocalizations. As this region also strongly responds to speech, it is unclear whether it is tightly associated with linguistic processing and is thus unique to humans. Using functional magnetic resona...

We quantified, by liquid chromatography tandemmass spectrometry, transporter protein expression of BSEP, MATE1, MRP3, MRP4, NTCP, and OCT1 in our human liver bank (n = 55) and determined the relationship between protein expression and sex, age and genotype. These data complement our previous work in the same liver bank where we quantified the protein expression of OATPs, BCRP, MDR1, and MRP2. I...

For many years, retrobulbar and peribulbar anesthesia were the standard for cataract surgery; however, many serious adverse effects have been reported (1, 2). With the introduction of modern phacoemulsification cataract surgery, topical anesthesia without retrobulbar or periocular injections has become a well-established, minimally invasive technique (3). The addition of intracameral lidocaine ...

(2R,3R,4R)-4-hydroxy-2-(hydroxymethyl)pyrrolidin-3-yl 4-O-(6-deoxyb-D-glucopyranosyl)-a-D-glucopyranoside (CS-1036), which is an a-amylase inhibitor, exhibited biphasic and sustained elimination with a long t1/2 (18.4–30.0 hours) in rats and monkeys, but exhibited a short t1/2 (3.7–7.9 hours) in humans. To clarify the species differences in the t1/2, the plasma protein binding of CS-1036 was ev...

This retrospective study evaluated the efficacy of radiotherapy used alone in macroscopic oral soft tissue sarcoma. Thirty-one dogs qualified for the study. Twenty dogs received curative radiotherapy (median total dose: 52.5 Gy) and eleven dogs were treated palliatively (3 x 8 Gy or 5 x 6 Gy). The time-to-progression for the curatively-treated dogs was 333 days versus 180 days for the palliativ...

OBJECTIVE Increasing evidence has demonstrated that microRNAs (miRNAs) play a critical role in the progression of metabolic disorders, including obesity-induced non-alcoholic fatty liver disease (NAFLD). In the present study, the expression and function of miR-367 were investigated. MATERIALS AND METHODS C57BL/6 male mice aged 8 weeks were fed with a normal diet (ND) or high-fat-diet (HFD). T...

Clear-cell renal cell carcinoma (ccRCC) is an aggressive and malignant kidney cancer which has the worst prognosis. Although microRNAs (miRNAs) have recently been identified as a novel class of regulators in oncogenesis and metastasis, there are few studies on their participation in ccRCC. In the present study, we observed that miR-367 expression was increased in both human ccRCC tissues and ce...

A sfilis ainda continua a ser um problema de saúde, sendo, o objetivo deste aprender é importante entre 2017 dezembro melhorar e epidemiológico sobre s. Diante disso, foi realizada uma pesquisa descritiva detalhada por meio da análise dos dados em pacientes prontuários atendidos referência do Oeste Paraná. Foram analisados ​​um total 877 prontuários, sendo 530 (%) casos sexo masculino 347 (40%)...

Development of protocols and media for culturing immune cells from marine invertebrates has not kept pace with advancements in mammalian immune cell culture, the latter having been driven by the need to understand the causes of and develop therapies for human and animal diseases. However, expansion of the aquaculture industry and the diseases that threaten these systems creates the need to deve...

INTRODUCTON The use of plants for treating diseases is as old as the human generations. Popular observations on the use and efficacy of medicinal plants significantly contribute to the disclosure of their therapeutic properties. India is the gateway of medicinal plants in the world with a rich source for food and medicine. From past several decades more importance are given to the research on m...