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We study the behaviour of the Ben-Yishai hypercolumn model (Ben-Yishai et al., Proc. Natl. Acad. Sci. USA 92 (1995) 3844) under presentation of oriented stimuli, having extended this model by including plastic a!erent (LGN to cortex) connections. We "nd that Hebbian plasticity creates a self-organising map and show that constraining or modifying the standard Hebb rule in a particular way will l...

The cell surface transmembrane receptor TM4SF5 has been implicated in hepatocellular carcinoma (HCC), but its candidacy as a therapeutic target has not been evaluated. Building on findings that immunization with a peptide vaccine targeting human TM4SF5 can exert prophylactic and therapeutic effects in a murine model of HCC, we developed a monoclonal antibody to characterize expression of TM4SF5...

One year ago the Human Proteome Project (HPP) leadership designated the baseline metrics for the Human Proteome Project to be based on neXtProt with a total of 13,664 proteins validated at protein evidence level 1 (PE1) by mass spectrometry, antibody-capture, Edman sequencing, or 3D structures. Corresponding chromosome-specific data were provided from PeptideAtlas, GPMdb, and Human Protein Atla...

Profiling the transcriptome that underlies biomass degradation by the fungus Trichoderma harzianum allows the identification of gene sequences with potential application in enzymatic hydrolysis processing. In the present study, the transcriptome of T. harzianum IOC-3844 was analyzed using RNA-seq technology. The sequencing generated 14.7 Gbp for downstream analyses. De novo assembly resulted in...

Caplan, R., Komaromi, J. & Rhodes, M. (1996) Obsessive-compulsive disorder, tattooing and bizarre sexual practices. British Journal of Psychiatry, 168, 379-380. Gardener, D.L. & Cowdry, R.W. (1985) Suicidal and parasuicidal behaviour in borderline personality disorder. Psychiatric Clinics of North America, 8,389-403. Hollander, E. (1999) Managing aggressive behaviour in patients with obsessive-...

Filamentous fungi from the genus Trichoderma have been widely investigated due to their considerable production of important biotechnological enzymes. Previous studies have demonstrated that the T. harzianum strain IOC-3844 has a high degree of cellulolytic activity. After excluding the native signal peptide, the open reading frame of the T. harzianum endoglucanase III enzyme was cloned in...

The low-cost production of cellulolytic complexes presenting high action at mild conditions and well-balanced cellulase activities is one of the major bottlenecks for the economical viability of the production of cellulosic ethanol. In the present paper, the filamentous fungus Trichoderma harzianum IOC-3844 was used for the production of cellulases from a pretreated sugarcane bagasse (namely, c...