The title compound, [Ni(C(25)H(19)N(4)O(2))(2)], which was obtained by the reaction of nickel(II) perchlorate with 2,6-diformyl-4-methyl-phenol and (tri-2-pyridylmeth-yl)amine in methanol solution, is a discrete monometallic complex. The Ni(II) atom is six-coordinated by the phenolate O, imine N and pyridine N atoms from two tridentate Schiff base ligands in a distorted NiN(4)O(2) octa-hedral g...

1. The action of piperazine on mammalian smooth, cardiac and skeletal muscles has been studied.2. Piperazine increased tone and produced a dose dependent contraction of isolated smooth muscle, which was antagonized by atropine.3. With cardiac muscle, piperazine depressed both the rate and force of contraction and was antagonized by atropine. At higher concentrations, a non-specific depression o...

The new Mannich base VEP (N,N’-bis-(5,5’-diethyl-barbituryl-1-methyl)-piperazine), has been synthetized by condensation of veronal with formaldehyde and piperazine following a Mannich procedure. The new binuclear complex Cu2VEP(X)4·4H2O , X=ClO4where VEP stands for N,N’-bis-(5,5’-diethyl-barbituryl-1-methyl)-piperazine, were obtained by metal ligand direct synthesis. Tetrahedral geometry of the...

Piperazine derivatives have been identified as new antidiabetic compounds. Structure-activity relationship studies in a series of 1-benzyl-4-alkyl-2-(4',5'-dihydro-1'H-imidazol-2'-yl)piperazines resulted in the identification of 1-methyl-4-(2', 4'-dichlorobenzyl)-2-(4',5'-dihydro-1'H-imidazol-2'-yl)piperazine, PMS 812 (S-21663), as a highly potent antidiabetic agent on a rat model of diabetes, ...

Cyclizine (1-benzhydryl-4-methyl-piperazine, CAS 82-92-8, CYC, I), a piperazine derivative, belongs to H1 antihistamine group of drugs that shows such pharmacological properties as anti-inflammatory, anti-allergic and anti-platelet effects, similar to other H1-receptor antagonists. In this study, two new tolyl and cumene derivatives of I (1-ethyl-4-[(p-isopropylphenyl) (p-tolyl) methyl]-piperaz...

the reaction of an equivalent of 2- mercaptoethyl ammonium chloride with an equivalent of 2,6-diformyl -4- methyl phenol produced monoamine which was reacted with half equivalent of 1,2-diamine ethane to produce ethylene-bis-6-(2-mercapto-ethyl-imine)-methyl -4- methyl phenol [h4l]. the ligand was reacted with metal ions[cr(iii), mn(ii), fe(ii), co(ii), ni(ii), cu(ii), zn(ii), cd(ii), and hg(ii...

RATIONALE Although amphetamine-type substances (ATS) have been investigated extensively in recent years, scarce data is available on screening tests for piperazine analogues. The need for a universal technique capable of detecting an extensive range of drug compounds becomes increasingly important with the continued emergence of novel drug analogues. METHODS Desorption electrospray ionisation...

The in vitro and in vivo metabolism of N-[1(R)-(1,3-benzodioxol-5-yl)butyl]-3,3-diethyl-2(S)-[4-[(4-methy l-1-piperazinyl)carbonyl]phenoxy]-4-oxo-1-azetidinecarboxamide (L-694,458) was studied in male Sprague-Dawley rats and rhesus monkeys. Analysis by LC-MS/MS and NMR revealed that the major metabolite generated in incubations with rat liver microsomes resulted from N-oxidation of the piperazi...

In the title mol-ecule, C(17)H(18)F(2)N(2), the dihedral angle between the benzene rings is 73.40 (3)°. The piperazine ring is close to an ideal chair conformation and the N-H hydrogen is in an equatorial position. In the crystal, molecules are linked via weak C-H⋯F hydrogen bonds.