Peptide receptor radionuclide therapy (PRRT) has been applied to the treatment of neuroendocrine tumors (NETs) for over two decades. However, improvement is still needed, and targeted alpha (TAT) with emitters such as lead-212 (212Pb) represents a promising avenue. A series ligands based on octreotate was developed. Lead-203 used an imaging surrogate selection best candidate studies lead-212. 2...

Fifteen Hereford and 47 crossbred heifers were allotted by breed and body weight to be artificially inseminated to one of two Angus sires selected for progeny birth weights (L = low; H = high). Forty-two of the heifers were randomly assigned to be slaughtered at 200, 215, 230, 245 or 260 d of gestation for measurement of fetal and placental characteristics. Twenty heifers were allowed to go to ...

ferula foetida (bunge) regel. is one of the most widespread and important ferula species with nutritional and medicinal applications. some phytochemicals with helpful cardiovascular effects have been isolated from ferula species. the present study was designed to evaluate the effects of hydroalcoholic extract of the stems of f. foetida in dexamethasone (dex)-induced hypertension in rats. hypert...

Dark matter halo merger trees are now routinely extracted from cosmological simulations of structure formation. These trees are frequently used as inputs to semi-analytic models of galaxy formation to provide the backbone within which galaxy formation takes place. By necessity, these merger trees are constructed from a finite set of discrete ‘snapshots’ of the N-body simulation and so have a li...

During the last six years we have attempted to determine the molecular basis of osteogenesis irnperfecta (01) by analyzing the collagenous proteins synthesized by dermal fibroblasts cultured from affected individuals, their parents, and other family members. During that time we have studied members of more than 400 unrelated families, or, we estimate, between one and five percent of all familie...