Results We included 24 pts [(21M,3F;10.6(4-16)yrs)]; median age at EoEd: 7(1-14)yrs. Average between symptom onset and EoEd:19±30 months. Average follow-up for 28 (5-60) months. Most frequent symptoms (%): dysphagia (54), impaction (50), GERD-like symptoms (42), abdominal and/or epigastric pain (42), vomiting (33). Most frequent onset symptom: dysphagia (46%). 96% of pts had prior history of at...

PURPOSE Young individuals with occlusive, proximal-limb deep vein thrombosis (DVT) who have acutely increased plasma levels of factor VIII and D-dimer are at high risk for postthrombotic syndrome (PTS) when treated with conventional anticoagulation alone. The present report is an evaluation of experience with adjunctive percutaneous mechanical thrombolysis (PMT) and/or percutaneous pharmacomech...

AIM To evaluate the downstaging of rectal cancer after preop R +/- CT. METHODS 392 patients (pts) with rectal cancer were observed. Only 172 pts (58%) with II and III stage cancer of middle and lower third were examined. Enrol-led pts were 168: 52 of them received preop R +/- CT (32 RT, 20 R + CT). Preop R +/- CT group included 14 middle third cancers (73%), 38 lower third (17%). In this grou...

The human gastrointestinal tract can be positively modulated by dietary supplementation of probiotic bacteria in combination with prebiotic carbohydrates. Here differential transcriptomics and functional genomics were used to identify genes in Lactobacillus acidophilus NCFM involved in the uptake and catabolism of 11 potential prebiotic compounds consisting of α- and β-linked galactosides and g...

Introduction: Previously, our group reported results from ibrutinib with rituximab in older mantle cell lymphoma (MCL) patients (pts) an atrial fibrillation rate of 22%. To develop a chemotherapy-free combination for elderly MCL pts, we designed this phase II clinical trial to investigate the efficacy and safety acalabrutinib (AR) as first line approach pts (≥65 yrs). Methods: We enrolled 50 pr...

OBJECTIVE The biventricular pacing (BVP) approach has good results in the treatment of congestive heart failure (CHF) in patients (pts) with disorders of intraventricular conduction. METHODS We have applied BVP to 28 pts, with left ventricular pacing using minitoracotomy in 3 pts and the transvenous approach via coronary sinus in 25 pts. The mean duration of the QRS complexes was 187 ms, in t...

Methods Analyzed group consists of 225 patients (pts) with MVD operated in Institute from 01.01.1081 till 01.01.2008. Average age was 51,3±6,1 yy. 151 (67,1%) pts belonged to IV NYHA class, 69 (30,7%) – to III and 5 (2,2%) pts to II. There were 69 (30,7%) males and 156 (69,3%) females. Mitral stenosis was in 191(84,9%) pts, combined MVD in 34 (15,1%) pts. Isolated OMC was performed In 146 (64,9...

OBJECTIVE The Hancock II (HII) is a second-generation porcine bioprosthesis introduced into clinical use in 1982. This study aimed to evaluate very long-term outcomes for the HII valve in a large patient population. METHODS Between May 1983 and November 1993, 517 consecutive patients (pts) (309 male, mean age: 64+/-9 years) underwent valve replacement (VR) surgery with HII, with 302 (58.4%) i...

Improving the annotation of sugar catabolism-related genes requires functional characterization. Our objective was to identify the genes necessary for lactose utilization by Lactobacillus gasseri ATCC 33323 (NCK334). The mechanism of lactose transport in many lactobacilli is a lactose/galactose-specific permease, yet no orthologue was found in NCK334. Characterization of an EI knockout strain [...