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Purpose: Our goal was to develop a potent humanized antibody against mouse/human CXCL12. This report summarized its in vitro and in vivo activities. Experimental Design: Cell surface binding and cell migration assays were used to select neutralizing hamster antibodies, followed by testing in several animal models. Monoclonal antibody (mAb) 30D8 was selected for humanization based on its in vitr...
Interaction between the t subunit of the DNA polymerase III holoenzyme and the DnaB helicase is critical for coupling the replicase and the primosomal apparatus at the replication fork (Kim, S., Dallmann, H. G., McHenry, C. S., and Marians, K. J. (1996) Cell 84, 643– 650). In the preceding manuscript, we reported the identification of five putative structural domains within the t subunit (Gao, ...
Aim: The aim of the study was to analyse the trends of allergy to the 10 most frequent contact allergens and to assess ageand sex-dependent changes of the trends in patients examined in 1996-2009. Material and methods: 4433 patients underwent patch tests with a set of allergens containing: potassium dichromate, nickel sulfate, cobalt chloride, 4-phenylenediamine, formaldehyde, thiuram mix, merc...
For k = 0, 1, 2,. .. let H k denote the harmonic number 0 3 we have p−1 k=1
PURPOSE To examine whether primary stenting as compared with primary balloon angioplasty reduces clinical outcomes in patients with myocardial infarction. METHODS Major medical databases from 1979 to March 2002 were searched for randomized controlled trials that compared primary stenting with balloon angioplasty in patients with myocardial infarction. Two independent reviewers selected and ex...
The Fed kept interest rates low and essentially unchanged during the late 1990s despite a booming economy and record-low unemployment. These interest rates were accommodative by historical standards. Nonetheless, inflation remained low. How did the Fed succeed in sustaining rapid economic growth without fueling inflation and inflationary expectations? In retrospect, it is evident that the produ...
The glycoprotein Ib (GPIb) complex is composed of GPIb covalently attached to GPIb and noncovalently complexed with GPIX and GPV. Patients with BernardSoulier syndrome demonstrate that mutations in either GPIb or GPIX result in an absence of platelet GPIb . This occurs through the interaction of GPIX with GPIb . The precise sites of interaction of GPIb with GPIX are not known. To characterize t...
OBJECTIVE Patients with type II diabetes have an increased risk of bladder cancer and are commonly treated with thiazolidinediones and angiotensin receptor blockers (ARBs), which have been linked to cancer risk. We explored the relationship between use of one or both of these medication types and incident bladder cancer among diabetic patients (diabetics) enrolled in Medicare. RESEARCH DESIGN...
BACKGROUND Brazil boasts a health scheme that aspires to provide universal coverage, but its surgical system has rarely been analysed. In an effort to strengthen surgical systems worldwide, the Lancet Commission on Global Surgery proposed a collection of 6 standardised indicators: 2-hour access to surgery, surgical workforce density, surgical volume, perioperative mortality rate (POMR) and prot...
OBJECTIVES Race/ethnicity and education are among the strongest social determinants of body mass index (BMI) throughout the life course, yet we know relatively little about how these social factors both independently and interactively contribute to the rate at which BMI changes from adolescence to midlife. The purpose of this study is to (1) examine variation in trajectories of BMI from adolesc...
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