نتایج جستجو برای: 4556

تعداد نتایج: 71  

Journal: :Cancer research 2017
Giuseppina Sannino Aruna Marchetto Thomas Kirchner Thomas G P Grünewald

The epithelial-to-mesenchymal transition (EMT) is a reversible process comprised of various subprograms via which epithelial cells reduce their intercellular adhesions and proliferative capacity while gaining a mesenchymal phenotype with increased migratory and invasive properties. This process has been well described in several carcinomas, which are cancers of epithelial origin, and is crucial...

Journal: :International Journal of Enviornment and Climate Change 2023

A field experiment was conducted during Kharif season-2019 at Agricultural Research Station, Chintamani, Karnataka. The consisted of four levels spacing (45 × 15, 45 30, 60 and 30 cm) three fertilizer (40:20:20, 60:40:40 80:60:60 kg NPK ha-1). arranged in a statistical design Factorial Randomized Complete Block Design (FRCBD) with replications to determine the influence different on growth, yie...

رشد روزافزون و شتابندة گردشگری موجب شده است بسیاری از صاحب‌نظران قرن 20 را «قرن گردشگری» بنامند. این صنعت بر حوزه‌های اقتصادی، اجتماعی و فرهنگی مانند مبادلات خارجی، درآمدها، اشتغال، قیمت‌ها، توزیع درآمدها، مهاجرت، تقسیم کار، آداب و رسوم و هنرها مؤثر است. هدف پژوهش حاضر، تبیین وضعیت زیرساخت‌های گردشگری در منطقة اورامانات استان کرمانشاه است. پس از گرد‌آوری داده‌ها، منطقة اورامانات و دیگر شه...

A. Barazandeh H. Nezamabadipour M. Ghaderi-Zefrehei M.R. Mohammadabadi,

Cattle supply an important source of nutrition for humans in the world. CpG islands (CGIs) are very important and useful, as they carry functionally relevant epigenetic loci for whole genome studies. As a matter of fact, there have been no formal analyses of CGIs at the DNA sequence level in cattle genomes and therefore this study was carried out to fill the gap. We used hidden markov model alg...

1999
L. A. Davidson R. E. Keller

Neurulation is the process by which progenitors of the central nervous system are shaped, separated from and brought beneath the epidermis. The cellular basis of these movements have been investigated in amphibians (Jacobson, 1981; Jacobson and Gordon, 1976; Keller et al., 1992b), chicken (Schoenwolf and Smith, 1990b; Smith and Schoenwolf, 1997) and mice (Bush et al., 1990; Sausedo and Schoenwo...

Journal: :Archives of internal medicine 2008
Thomas D Sequist Garrett M Fitzmaurice Richard Marshall Shimon Shaykevich Dana Gelb Safran John Z Ayanian

BACKGROUND Little information is available regarding variations in diabetes mellitus (DM) outcomes by race at the level of individual physicians. METHODS We identified 90 primary physicians caring for at least 5 white and 5 black adults with DM across 13 ambulatory sites and calculated rates of ideal control of hemoglobin A(1c) (HbA(1c)) (<7.0%), low-density lipoprotein cholesterol (LDL-C) (<...

Journal: :Molecular cancer therapeutics 2009
Wing Lam Scott Bussom Yung-Chi Cheng

Beta-L-dioxolane-cytidine (L-OddC; BCH-4556; troxacitabine), a novel L-configuration deoxycytidine analogue, was under clinical trials for treating cancer. The cytotoxicity of L-OddC is dependent on its phosphorylation to L-OddCTP by phosphoglycerate kinase (PGK) and its subsequent addition into nuclear DNA. Because PGK is induced with hypoxia, the expression of hypoxia-inducible factor-1alpha ...

Journal: :Lung cancer 2005
T Le Chevalier G Scagliotti R Natale S Danson R Rosell R Stahel P Thomas R M Rudd J Vansteenkiste N Thatcher C Manegold J-L Pujol N van Zandwijk C Gridelli J P van Meerbeeck L Crino A Brown P Fitzgerald M Aristides J H Schiller

PURPOSE Gemcitabine-platinum combination activity has been clearly established in a number of phase II studies. It has also been compared against other combinations in many phase III trials. It is generally believed that all such regimens have an equivalent impact on survival. This meta-analysis aims to quantify the treatment effect of gemcitabine plus a platinum agent in the treatment of advan...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Tuukka Mäkinen Teuvo L J Tammela Ulf-Håkan Stenman Liisa Määttänen Jussi Aro Harri Juusela Paula Martikainen Matti Hakama Anssi Auvinen

PURPOSE Large randomized trials provide the only valid means of quantifying the benefits and drawbacks of prostate-specific antigen (PSA) screening, but the follow-up of ongoing studies is still too short to allow evaluation of mortality. We report here the intermediate indicators of screening efficacy from the second round of the Finnish trial. EXPERIMENTAL DESIGN The Finnish trial, with app...

Journal: :Plant science : an international journal of experimental plant biology 2016
Deepak Bajaj Hari D Upadhyaya Shouvik Das Vinod Kumar C L L Gowda Shivali Sharma Akhilesh K Tyagi Swarup K Parida

The present study exploited integrated genomics-assisted breeding strategy for genetic dissection of complex branch number quantitative trait in chickpea. Candidate gene-based association analysis in a branch number association panel was performed by utilizing the genotyping data of 401 SNP allelic variants mined from 27 known cloned branch number gene orthologs of chickpea. The genome-wide ass...

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