objective(s): in this work a new possible agent for radiosynovectomy has been targeted for articular pain palliation. materials and methods: lu-177 of 2.6-3 gbq/mg specific activity was obtained by irradiation of natural lu2o3 sample with thermal neutron flux of 4 × 1013 n.cm-2.s-1. the product was converted into chloride form which was further used for labeling of 177lu-phytate complex and che...

Introduction:Owing to its favorable radionuclidic characteristics, such as tl/2 = 6.73 day and Eβ (max) = 497 keV and ease of its large-scale production using medium flux research reactors, lutetium-177 (177Lu) is an attractive radionuclide for various therapeutic applications. No carrier added (NCA) 177Lu was obtained by thermal neut...

The objective of having a process operate with a capability index of 1.5 to 2.0 is a reasonable and economic objective. However, the arguments commonly used to explain the economics of this objective can only be described as statistical snake oil—a blend of tortured computations and incompatible, highly questionable assumptions, having a hypnotic effect and often resulting in a suspension of cr...

The objective is to evaluate in situ detection of living mycobacterium tuberculosis rRNA using Mycobacterium Tuberculosis Direct Assay (MTD) and its clinical significance in early diagnosis of extrapulmonary tuberculosis. 86 patients having been diagnosed to have extrapulmonary tuberculosis including tuberculous peritonitis (n=22), lymphatic tuberculosis (n=21), tuberculous meningitis (n=15), H...

OBJECTIVE: To review the literature about the positive predictive value of Breast Imaging Reporting and Data System (BI-RADS®) categories 3, 4 and 5. MATERIALS AND METHODS: A research was performed in the online Medline database, entering the terms “predictive value” and “BI-RADS”. Eleven studies were included in this review. RESULTS: The positive predictive values ranged respectively between 0...

Cervical cancer is the second most common cancer in women in the world. In this study, we explore tumor markers and microRNA-466 combination for cervical cancer screening. Tumor markers were measured by the methods of electro-chemiluminescent immunoassay and enzyme immunoassay. The microRNA-466 was performed by quantitative real-time polymerase chain reaction. Among normal group, hyperplasia gr...

Introduction: Somatostatin receptors expressed on a wide range of human tumors, are potential targets for the peptide receptor radionuclide therapy (PRRT). In this study, 177Lu-[DOTA-DPhe1, Tyr3]octreotide (177Lu-DOTATOC) as an agent for PRRT was prepared and its biodistribution was studied in rats. Methods:The ...

Department of Physiology, Nagoya University Graduate School of Medicine, Nagoya 466–8550, Japan (M.T., T.F., M.S., H.T.); International Cooperative Research Project/Solution-Oriented Research for Science and Technology, Cell Mechanosensing Project, Japan Science and Technology Agency, Nagoya 466–8550, Japan (M.S.); and Department of Molecular Physiology, National Institute for Physiological Sci...

Cyclooxygenase (COX)-inhibiting nitric oxide (NO) donors (CINODs) are designed to inhibit COX-1 and COX-2 while releasing NO. COX inhibition is responsible for anti-inflammatory and pain-relieving effects, whereas NO donation can improve microcirculation and exert anti-inflammatory and antioxidant actions. In an in vivo mouse model of bleomycin-induced lung fibrosis, we evaluated whether a prot...