The use of the renewable platform molecule 5-hydroxymethylfurfural (5-HMF) in multi-component reaction with a diamine and an alkynone to generate seven-membered 1,5-benzodiazepines is described. Due sensitivity 5-HMF strong acidic basic conditions, investigation required in-depth revisit parameters as compared benchmark aldehydes. Among catalysts/solvents couples, ammonium acetate ethanol prove...

A review of the published case reports of adverse behavioral episodes or unexpected psychopathology in patients taking benzodiazepines was undertaken in an attempt to determine if these adverse or unexpected events are more likely to occur with alprazolam when compared with other currently marketed benzodiazepines. Adverse behavioral phenomena and unexpected psychopathology were divided into th...

Current pharmacological treatment of insomnia involves the use of sedative-hypnotic benzodiazepine and non-benzodiazepine drugs. Although benzodiazepines improve sleep, their multiple adverse effects hamper their application. Adverse effects include impairment of memory and cognitive functions, next-day hangover and dependence. Non-benzodiazepines are effective for initiating sleep but are not ...

A series of 5-aryl-1,4-benzodiazepines with chloro- or fluoro-substituents in the second ring have been synthesized and their anti-inflammatory, myeloperoxidase and anticancer properties studied. The synthesized compounds showed potential anti-inflammatory and anticancer activities, which were enhanced in the presence of a chloro-substituent in the second ring of the 5-aryl-1,4- benzodiazepine.

Objective: Benzodiazepines are a group of psychotropic drugs that are frequently prescribed. There are many published studies indicate that these drugs can affect driving ability. These studies are either epidemiological or experimental. Some efforts have been made recently toward the establishment of legal limits for benzodiazepines in the blood of drivers. Methods: A systematic review of the ...

background: the aim of this study was to evaluate and compare the clinical and ‎electrocardiographic (ecg) manifestations of benzodiazepines (bzs).‎ methods: in this retrospective study, all bz-poisoned patients hospitalized at loghman ‎hakim hospital between september 2010 and march 2011 were evaluated. patients’ ‎information including age, sex, time elapsed between the ingestion and presentat...

BACKGROUND 1, 5-Benzodiazepines have been investigated extensively by organic chemists due to their medicinal and pharmacological properties. These compounds are synthesized by condensation of o-phenylenediamines with carbonyl compounds in the presence of acid catalysts. OBJECTIVES During our studies on the application of silica resin with acid functional moieties, we found that SiO2/H2SO4 mi...

Prescribe Benzodiazepines? Not Me! Modern guidelines for psychopharmacologic treatment of anxiety disorders have evolved from recommending GABAergic (gammaaminobutryic acid) benzodiazepines to recommending serotonergic agents for first-line use. This trend, along with adverse publicity about the dependence potential of benzodiazepines, might lead one to suspect that benzodiazepines, once promin...

Background & Objective: Some drugs like benzodiazepines have been associated with an increased incidence of infections by making weak immune system. Here, we determined the effect of use of benzodiazepines on the occurrence of community acquired pneumonia (CAP). Methods: We used Taiwan National Health Insurance Claim Database of 22 million (2002) population to investigate the association of ben...

conformations and electronic properties of a series of imidazobenzodiazepines are investigated by am1 semi-empirical quantum mechanics method. it is shown that substitution of cl in position 7 instead of 8, changes the geometry of the seven membered lactam ring; this may put the n5 nitrogen in a better positon to act as a hydrogen bond acceptor, and the phenyl ring in position 6 is probably mor...