Chondroitin sulfate and sodium alginate were incorporated in different ratios to prepare glutaraldehyde (GA) crosslinked microspheres by water-in-oil emulsion crosslinking method for delivery of 5-flurouracil (5-FU) to colon. Chemical interaction, surface morphology, thermal degradability, crystallinity evaluation, elemental analysis and drug release results were computed by using FTIR, SEM, DS...

Potentilla fulgens L., a locally used medicinal plant with reported hypoglycemic, antihyperglycemic, and anti-tumor properties was studied. The polar extracts of P. fulgens L. were assessed and found to induce cytotoxic response at different concentrations against a panel of human carcinoma cells such as THP-1 leukemia, HEP-2 liver, OVCAR-5 ovary, A-549 lung, PC-3 prostrate, and SF-295 neurobla...

The aim of the present study is to evaluate the effect of column (SU I, SU II, SU III) extracts of the plant Murraya koenigi against in vitro (short term incubation method, SU I, SU II, SU III) and in vivo (Dalton’s Ascitic Lymphoma, SU II) has been evaluated in male swiss albino mice. DAL cells were injected intraperitoneally (10 cells) to the mice. Two days after cells injection the animals w...

Colorectal cancers (CRCs) invariably become hypoxic as they enlarge, and this places unique metabolic demands upon the tumor cells. Hypoxic stress can enhance the invasiveness of cancer cells and induce chemoresistance. c-Myc, an oncogene regulated by hypoxia inducible factors (HIFs), plays a critical role in cell proliferation and metabolism. However, the interplay between c-Myc and HIFs and i...