Recent evidence from a variety of laboratory studies suggests that the central effects of ethanol (EtOH) are mediated by serotonin 5-HT3 receptors. Notably, EtOH is able to potentiate 5-HT action on 5-HT3 ionophore, and 5-HT3 antagonists are known to reduce certain effects of EtOH. In the present study, we evaluated the effects of two agonists of 5-HT3 receptors, 2-methyl-5-HT (2-Me-5-HT) and m...

BACKGROUND 5-hydroxytryptamine receptor 2A (5-HT2A) participates in diverse psychiatric disorders by regulating the activity of serotonin. Some previous studies have also suggested that the receptor is involved in cognitive abilities of disease groups. We hypothesize that some functional genetic variants in 5-HT2A have certain specific influences on cognitive abilities in a normal population. ...

We evaluated the possibility that serotonin (5-HT) mediates defecation induced by corticotropin-releasing hormone (CRH) exogenously administered or released from the central nervous system by stress via the 5-HT3 receptor in rats. Intracerebroventricular (ICV) injection of CRH (1, 3, and 10 μg/rat) dose dependently increased the number of stools excreted in rats, whereas intravenous (IV) inject...

BACKGROUND/AIMS Solifenacin, a muscarinic type 3 receptor antagonist, is used to treat overactive bladder in adults. The aim of this study is to examine the efficacy of solifenacin on the symptomatic relief of diarrhea predominant irritable bowel syndrome (IBS-D). METHODS A total of 20 patients with IBS-D were enrolled. After a 2-week observation period, all participants received solifenacin ...

The aim of the present study was to determine whether alterations in 5-hydroxytryptamine (5-HT)(1A) receptors would be found in knockout mice lacking the serotonin transporter (5-HTT). Hypothermic and neuroendocrine responses to the 5-HT(1A) agonist 8-hydroxy-2-(di-n-propylamino)tetraline (8-OH-DPAT) were used to examine the function of 5-HT(1A) receptors. Initial studies evaluated the dose-res...

Objective: Although pharmacological studies have indicated that serotonin (5-HT)-evoked contraction of the human coronary artery is mediated by 5-HT -like and 5-HT receptors, the gene expression of 5-HT receptors is still unclear. We examined mRNA expression of 1 2 5-HT and 5-HT receptor subtypes in human coronary arteries. Methods: Total RNA was extracted from human coronary arteries of 14 1 2...

The ability of selective serotonin (5-HT) receptor agonists to reduce the extracellular concentration of 5-HT was examined in the striatum of awake, unrestrained mice by in vivo microdialysis. Systemic administration of either 8-OH-PIPAT (R-(+)-trans-8-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)] aminotetralin), a novel 5-HT(1A) receptor agonist, or CP 94,253, a selective 5-HT(1B) receptor ag...