Ethanolic extracts of six Indian medicinal plants, piperine, guggulsterone E and guggulsterone Z were tested for cytotoxicity using brine shrimp lethality test. Piper longum showed most potent cytotoxic activity. Piperine, guggulsterone E and guggulsterone Z showed potent activity with LC(50) 2.4, 8.9 and 4.9, respectively.

Ever since cloning the classic iv (inversedviscerum) mutation identified the "left-right dynein" (lrd) gene in mice, most research on body laterality determination has focused on its function in motile cilia at the node embryonic organizer. This model is attractive, as it links chirality of cilia architecture to asymmetry development. However, lrd is also expressed in blastocysts and embryonic ...

Myeloid cell leukemia-1 (Mcl-1), an anti-apoptotic Bcl-2 protein, regulates neural precursor (NPC) survival in both the developing and adult mammalian nervous system. It is unclear when during neurogenic period Mcl-1 becomes necessary for NPC whether Bax sole pro-apoptotic target of Mcl-1. To address these questions, we used system-specific Nestin-Cre conditional knockout mouse line (Mcl-1 CKO)...

purpose: in recent years high explosive bomb attacks have been increasingly directed against   civil structures by various terrorist organizations. this paper describes a numerical method for   assessing the interaction of high explosive air blast within the complex geometrical type of a   congested urban environment.   materials and methods: the first step in predicting blast effects on a targ...

Escherichia coli sequence type (ST)131 is an emerging disseminated public health threat implicated in multidrug-resistant extraintestinal infections worldwide. Although the majority of ST131 isolates belong to O25b:H4 serotype, new variants with different serotypes, STs using the discriminative multilocus sequence typing scheme of Pasteur Institute, and virulence-gene profiles (virotypes) have ...

Hybrid lethality is a type of reproductive isolation barrier observed in two developmental stages, hybrid embryos (hybrid seeds) and seedlings. has been reported many plant species limits distant hybridization breeding including interspecific intergeneric hybridization, which increases genetic diversity contributes to produce new germplasm for agricultural purposes. Recent studies have provided...

The main objective of this study was to quantify reduction Salmonella and Listeria monocytogenes during salami production phases. Salami batter prepared, inoculated with L. monocytogenes, stuffed into casings (50 80 mm), subjected four processing trials (A-D). Trials A/B included fermentation (32 °C, 95% RH, 24 h) drying (15 72% 31 d). C/D were identical except mm dried 60 d both diameters comp...