We conducted a combined biochemical modulation trial of N-(phosphonacetyl)-L-aspartate (PALA), dipyridamole (DP), and fluorouracil (5-FU) in patients with cancer. Eighty-eight patients with advanced cancer were entered into this Phase I trial. During the first part of the study, four doses of PALA (125, 250, 500, and 1000 mg/m2, administered on day 1) were evaluated to determine the PALA dose w...

BACKGROUND To compare the effectiveness of liposomal tobramycin or polymyxin B against Pseudomonas aeruginosa in the Cystic Fibrosis (CF) sputum and its inhibition by common polyanionic components such as DNA, F-actin, lipopolysaccharides (LPS), and lipoteichoic acid (LTA). METHODOLOGY Liposomal formulations were prepared from a mixture of 1,2-Dimyristoyl-sn-Glycero-3-Phosphocholine (DMPC) or...

in order to study the effects of silver thiosulfate (0.02, 0.05, 0.1 and 0.2 mm), humic acid (100, 500 and 1000 mg l-1), nano silver (5, 10, 25 mg l-1), salisilicacid (1, 2 and 4 mm) and sucrose (1%, 2.5% and 5%) on the vase life and some qualitative characteristics of cut narcissus var duch master floweres, two expriments were counducted in postharvest laboratory of mohaghegh ardabili universi...

OBJECTIVE To evaluate the efficacy and safety of three dosing and repeat treatment regimens of rituximab (RTX) plus MTX in patients with active RA. METHODS Patients with active RA despite stable MTX (10-25 mg/week) were randomly assigned to one of the three treatment regimens comprising two courses of RTX given 24 weeks apart: 2 x 500 and 2 x 500 mg; 2 x 500 and 2 x 1000 mg (dose escalation);...

Avermectin-grafted-N,O-carboxymethyl chitosan (NOCC) derivative was obtained by esterification reaction using dicyclohexylcarbodiimide (DCC) as dehydrating agent and 4-methylaminopyridine as catalyst. The structures of the conjugate were confirmed by FT-IR, (1)H NMR, and XRD. Insecticidal activities against armyworms, carmine spider mites, black bean aphids, and brown plant hoppers were investi...

This study demonstrates the acute toxicity of lanthanum oxide nanoparticles (La2O3 NP) on two sentinel aquatic species, fresh-water microalgae Chlorella sp. and the crustacean Daphnia magna. The morphology, size and charge of the nanoparticles were systematically studied. The algal growth inhibition assay confirmed absence of toxic effects of La2O3 NP on Chlorella sp., even at higher concentrat...

This research was conducted to isolate and identify phenol tolerating bacteria from petroleum contaminated sites. Two bacterial species were isolated sites (NWPK NWPKD). The isolation based on morphological, microscopic molecular identification. total viable counts of utilizing NWPK NWPKD are 2.71x107 4.0x106 cfu/g respectively. isolates showed capacity tolerance at 500 mg/L, 1000 mg/L 1500 whe...

Introduction: In order to clarify the characteristics of different administration routes and to optimize the dosage, carnitine kinetics was investigated under oral and intravenous supplementation. Methods: Lcarnitine was administered orally (900mg) for 12months, intravenously (1000 mg) for 3months and (500mg) for 3months sequentially in 18 chronic hemodialysis patients. Plasma free and acyl car...

Background: Euphorbia pulcherrima belongs to the family: Euphorbiaceae and Genus: Euphorbia. Many species of Euphorbia have been reported as having beneficial properties like anticonvulsive effect. However, little study has been done and published on Euphorbia pulcherrima (Lalupate). In the present study we evaluated the anticonvulsant properties of Euphorbia pulcherrima by using various convul...