We propose a large-scale hologram calculation using WAvelet ShrinkAgeBased superpositIon (WASABI), a wavelet transform-based algorithm. An image-type hologram calculated using the WASABI method is printed on a glass substrate with the resolution of 65, 536×65, 536 pixels and a pixel pitch of 1μm. The hologram calculation time amounts to approximately 354 s on a commercial CPU, which is approxim...

51) Int. Cl." ...................... C12P 21/00; C12N 15/00; C12N 1/00; A61K 39/00 52 U.S. Cl. ................................... 435/68; 435/172.3; 435/253; 435/317; 514/8; 514/12; 530/350; 530/351; 530/395; 530/808; 424/85; 424/88; 536/27 58) Field of Search ................... 435/68, 70,240, 243, 435/253, 172.3, 317; 514/12, 8; 260/112.5 R; 935/9, 11-13, 65; 536/27; 424/88, 85; 530/350, 35...

We present an analysis of XMM-Newton and RXTE data from three observations of the neutron star LMXB 4U 1636-536. The X-ray spectra show clear evidence of a broad, asymmetric iron emission line extending over the energy range 4–9 keV. The line profile is consistent with relativistically broadened Fe K-α emission from the inner accretion disk. The Fe K-α line in 4U 1636-536 is considerably broade...

We present the results of a study with the Swift Burst Alert Telescope in the 14 – 195 keV range of the long-term variability of 5 low mass X-ray binaries with reported or suspected super-orbital periods — 4U 1636-536, 4U 1820-303, 4U 1916-053, Cyg X-2 and Sco X-1. No significant periodic modulation was detected around the previously reported values in the 4U 1916-053, Cyg X-2 or Sco X-1 light ...

The estrogen receptor (ER), of which there are two forms, ERalpha and ERbeta, is a ligand-modulated transcription factor important in both normal biology and as a target for agents to prevent and treat breast cancer. Crystallographic studies of the ERalpha ligand-binding domain suggest that Leu-536 may be involved in hydrophobic interactions at the start of a helix, "helix 12," that is crucial ...

The purpose of this study was to determine the effects of inhibitors of Rho kinase (ROK) and matrix metalloproteinases (MMPs) on angiogenesis and tumor growth and to evaluate ROK activity in human prostate cancer PC3 cells and endothelial cells (HUVECs). Vacuolation by endothelial cells and lumen formation, the earliest detectable stages of angiogenesis, were inhibited by the ROK inhibitor Wf-5...

Fibrolamellar hepatocellular carcinoma (FLHCC) is an aggressive neoplasm due to high frequency of recurrence after surgical resection and resistance to chemotherapy and radiation therapy. Activation of transcription factor NF-kB signaling pathway has been recognized for involvement in progression of various malignant neoplasms. The role of NF-kB pathway in FLHCC has not been studied to date. Fo...