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BACKGROUND Type 1 insulin-like growth factor receptor (IGF-1R) mediates resistance to chemotherapy and targeted agents. This study assessed the safety, pharmacokinetics (PK), and tolerability of humanized IGF-1R antibody AVE1642 with other cancer treatments. PATIENTS Patients with advanced solid tumors received three weekly AVE1642 dosed at 6 mg/kg, chosen following previous study, with 75 (c...
We report on high-speed optical photometry of the radio positions of two young rotation-powered pulsars. No pulsations were detected from the optical counterpart proposed by Caraveo et al. (1994) for PSR B1509–58, with a 2σ upper limit on the pulsed fraction of < 12%, significantly lower than that measured in the five known optical pulsars. Given its low pulsed fraction, high optical luminosity...
OBJECTIVES To analyse the oral health status of children and adults in rural and urban areas of Burkina Faso; to provide epidemiological data for planning and evaluation of oral health care programmes. DESIGN Cross-sectional survey including different ethnic and socio-economic groups. SAMPLE AND METHODS Multistage cluster sampling of households in urban areas and random samples of participa...
Hart, K.P. and J. van Mill, Discrete sets and the maximal totally bounded group topology, Journal of Pure and Applied Algebra 70 (1991) 73-80. If G is an Abelian group, then G # is G with its maximal totally bounded group topology. We prove that every A c G# contains a closed (in G#) and discrete subset B such that lB1 = IAl. This answers a question posed by Eric van Douwen. We also present an ...
drought is transient phenomenon , slow , repetitive and integral part of the climate of each region. drought begins with a substantial reduction in precipitation over the long-term average rainfall and over time, reduced soil moisture and surface and ground water resources will continue to decrease. this phenomenon is the most important in bakhtegan basin because of its importance in strategic ...
Infection with some genotypes of human papillomavirus (HPV) is the most important risk factor associated with cervical cancer (CC). Throughout the world, HPV type 58 prevalence varies from one region to another; it is higher in women from certain countries in Asia and Latin America, such as China and Mexico. Although intratypic variants have been reported on a few occasions, our knowledge about...
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