of Purpose: A comparison of long term effect on IOP and complications trabeculectomies performed with the adjunct of either postoperative 5 fluorouracil(5FU) or peroperative mitomycin C(MMC) in 100 cases of high risk glaucoma. &&&We prospectwly studied 52 eyes of46 patients treated with MMC (Follow up 15i8.7111) and compared it with a retrospective scrie of48 eyes 01 35 patients treated with 5F...

of Purpose: A comparison of long term effect on IOP and complications trabeculectomies performed with the adjunct of either postoperative 5 fluorouracil(5FU) or peroperative mitomycin C(MMC) in 100 cases of high risk glaucoma. &&&We prospectwly studied 52 eyes of46 patients treated with MMC (Follow up 15i8.7111) and compared it with a retrospective scrie of48 eyes 01 35 patients treated with 5F...

A recent study showed that both 5-fluorouracil (5FU)-stimulated apoptosis and Fas-mediated apoptosis in human endometrial adenocarcinoma cells are enhanced by targeted knockdown of endogenous death-associated protein kinase (DAPK) with DAPK small-interfering RNAs. Therefore, we investigated the DAPK survival signals in three 5FU-resistant subclone...

Capecitabine, an oral prodrug of 5-fluorouracil (5FU), has been integrated into the management of multiple cancer types because of convenience of administration and efficacy comparable with 5fu. Cardiotoxicity induced by 5FU-in particular angina-has been well described in the literature, but reports of adverse cardiac events with capecitabine are also emerging. The mechanism underlying 5FU card...

BACKGROUND Despite the myriad options available, there is no universally accepted treatment for keloids. This study has compared intralesional triamcinolone acetonide, 5-fluorouracil, and their combination in treatment of keloids. METHODS In this randomized parallel group study, 60 patients were enrolled and randomly allocated to three groups. Patients received intralesional injections of tr...

We determined the urinary excretion of 5-fluorouracil (5FU) and its metabolites during six days of chemotherapy, using the non-invasive approach of 19F nuclear magnetic resonance. With this method, which requires no labeled drug, one can study the biological sample directly and simultaneously identify and quantify all the fluorinated metabolites. The daily urinary excretion of 5FU and its metab...

Thymidylate synthase (TS) is a cell cycle regulated enzyme. It increases during proliferation and has a higher activity during the S-phase in order to provide the cell with sufficient dTTP to facilitate DNA synthesis. Hence inhibition of cyclin dependent kinases (CdK) may lead to a decrease of TS and enhance the inhibition of TS. A number of CdKs control progress of the cell cycle together with...

A rat colon tumour model of liver metastases was used to administer 5-fluorouracil (5FU) by intraperitoneal (i.p.) bolus injection (50 mg/kg), isolated liver perfusion (ILP, 150 mg/kg) and hepatic artery infusion (HAI, 50 mg/kg). The biochemical effect of 5FU, delivered by different routes, on its target enzyme thymidylate synthase (TS) was studied in both tumour and normal tissues of the rat. ...

The inhibition of thymidylate synthase (TS) by the 5-fluorouraciI (5FU) metabolite 5-fluorodeoxyuridine monophosphate can be biochem ically modulated by leucovorin (LV). LV administration increases the level of reduced folates in tissues, which promotes the inhibition of TS. We have studied the antitumor effect, free 5-fluorodeoxyuridine monophosphate levels, and inhibition of TS in two murine ...

The inhibition of thymidylate synthase (TS) by the 5-fluorouraciI (5FU) metabolite 5-fluorodeoxyuridine monophosphate can be biochem ically modulated by leucovorin (LV). LV administration increases the level of reduced folates in tissues, which promotes the inhibition of TS. We have studied the antitumor effect, free 5-fluorodeoxyuridine monophosphate levels, and inhibition of TS in two murine ...