The allosteric coupling free energy between ligands fructose-6-phosphate (Fru-6-P) and phospho(enol)pyruvate (PEP) for phosphofructokinase-1 (PFK) from the moderate thermophile, Bacillus stearothermophilus (BsPFK), results from compensating enthalpy and entropy components. In BsPFK the positive coupling free energy that defines inhibition is opposite in sign from the negative enthalpy term and ...

Methylated guanine damage at O6 position (i.e. O6MG) is dangerous due to its mutagenic and carcinogenic character that often gives rise to G:C-A:T mutation. However, the reason for this mutagenicity is not known precisely and has been a matter of controversy. Further, although it is known that O6-alkylguanine-DNA alkyltransferase (AGT) repairs O6MG paired with cytosine in DNA, the complete mech...

introduction: the aim of this study was to evaluate the composite surface treated by different powers of erbium-doped yttrium aluminum garnet (er:yag) laser in comparison with bur preparation via scanning electron microscope. methods: fourteen composite resin blocks with 15× 10 × 10 mm dimensions were used in this study. the samples were divided to seven groups as follow: group 1 (power: 1 w, e...