Most proteins must fold into precise three-dimensional conformations to fulfill their biological functions. Here we review recent concepts emerging from studies of protein folding in vitro and in vivo, with a focus on how proteins navigate the complex folding energy landscape inside cells with the aid of molecular chaperones. Understanding these reactions is also of considerable medical relevan...

A new aporphine alkaloid, 7-epi-duguetine (1) together with one known alkaloid, dicentrinone (2), and four known flavonoids, quercetin 3,7-dimethyl ether 3′-O-α-L-rhamnopyranosyl-(12)-β-D-glucopyranoside (3), galangin 5-methyl ether (4), 5,7-dimethoxy-3-hydroxyflavone (5), and 3,5,7-trimethoxyflavone (6), were isolated from the leaves of Dasymaschalon acuminatum, a new plant species which has ...

Five flavones were isolated from Chrysanthemum coronarium L., four of which were isolated for the first time from the genus Chrysanthemum. Two were the flavonoid aglycones 5,7-dihydroxy-3,6,4'-trimethoxyflavone (1) and scutellarin-6,7-dimethyl ether (2). A new flavonoid glycoside, apigenin-7-O-[2"(6'''-O-beta-D-acetylglucopyranosyl)]-6"-O-acetylglucopyranoside (3), along with two known ones, i....