In the course of our search for newanti-tumor substances, it was found that a strain ofAcremonium sp. produced a cytotoxic metabolite 1 against tumor cells. It was identified as heptelidic acid chlorohydrin which was formerly reported as a toxic compound to spruce budwormdescribed by Calhoun et al}\ The producing fungi strain No. 618 was identified as Acremonium species, and named Acremonium sp...
