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PURPOSE Fas-Fas ligand (FasL)-mediated death pathway is important in the life and death of immune cells and, therefore, influences immune surveillance of carcinogenesis. This study examined the association between functional variants of Fas (-1377G-->A and -670A-->G), FasL (-844T-->C), and caspase-8 (CASP8) six-nucleotide deletion polymorphism (-652 6N ins-->del) and risk of pancreatic cancer. ...

Blockade of hERG K(+) channels in the heart is an unintentional side effect of many drugs and can induce cardiac arrhythmia and sudden death. It has become common practice in the past few years to screen compounds for hERG channel activity early during the drug discovery process. Understanding the molecular basis of drug binding to hERG is crucial for the rational design of medications devoid o...

aceae) is frequently taken orally, as a crude substance, as a traditional medicine in Asian countries. The major components of ginseng are ginsenosides, which contain an aglycone with a dammarane skeleton. These ginsenosides have been reported to exhibit various biological activities, including anti-inflammatory action and antitumor effects (inhibition of tumor-induced angiogenesis and the prev...

BACKGROUND Raised plasma ferritin concentrations occur unexpectedly during iron studies done by primary care physicians. Plasma ferritin concentration has been positively associated with alcohol use among men. AIM To determine the post-test probability that men in the community with raised plasma ferritin concentrations are hazardous drinkers. METHODS The subjects were 152 men, randomly sel...

PURPOSE Caspase-8 (CASP8) is a key regulator of apoptosis or programmed cell death, an essential defense mechanism against hyperproliferation and malignancy. We hypothesized that the variants in the CASP8 gene are associated with risk of bladder cancer. EXPERIMENTAL DESIGN In a hospital-based case-control study of 365 case patients with newly diagnosed bladder transitional cell carcinoma and ...

Ectodomain cleavage of the ErbB-4 receptor tyrosine kinase generates a membrane-associated fragment of 80 kDa (m80) that has been subjected to N-terminal sequencing. The sequence obtained shows that the N terminus of this fragment begins with Ser-652 of ErbB-4. When a 12-residue peptide corresponding to ErbB-4 residues 646-657 was incubated with recombinant tumor necrosis factor-alpha-convertin...