Background: The older Hispanic population of the U.S. is growing at a tremendous rate. While ethnic-related risk and complications of diabetes are widely-acknowledged for older Hispanics, less is known about how health related quality of life is affected in this population. Methods: Cross-sectional study assessing differences in health related quality of life between older Mexican Americans wit...

Background: There is at present a lack of knowledge of time trends in health related quality of life (HRQL) in common patients with coronary artery disease (CAD) treated in ordinary care. The objective of this study is to assess and compare time trends of health related quality of life (HRQL) and chest pain in patients with coronary artery disease. Methods: 253 consecutive CAD patients in Stock...

Background: Hemodialysis (HD) and peritoneal dialysis (PD) are important renal replacement treatment in end stage renal disease (ESRD), but the comparison of quality of life (QOL) and causes of hospitalisation between the two modalities in China is lacking. In the present study, we compared the two modalities in a multi-center study. Subjects and methods: Six hundred and fifty four HD and 408 P...

This report records and discusses the Fourth Workshop on Sustainable Software for Science: Practice and Experiences (WSSSPE4). The report includes a description of the keynote presentation of the workshop, the mission and vision statements that were drafted at the workshop and finalized shortly after it, a set of idea papers, position papers, experience papers, demos, and lightning talks, and a...

Background: Dizziness adversely affects an individual?s well-being. However, its impact is not only influenced by its physical manifestations, but also by its subjective importance to the patient. Appropriately assessing the subjective burden of dizziness is difficult. The Pictorial-Representation of Illnessand Self-Measure (PRISM), on which patients illustrate the distance between their ‘self?...

Background: Many factors are proposed to be associated with health-related quality of life. Knowledge of health factors associated to development of a good health-related quality of life could be of use in clinical practice and public health work. The aim of this study was to investigate the associations between suggested health factors and health-related quality of life at baseline and in an e...

A response to Norman GR 'Discrimination and reliability: equal partners?' and Wyrwich KW 'Understanding the role of discriminative instruments in HRQoL research: can Ferguson's Delta help?' Response I would like to thank Norman and Wyrwich for their close reading of my article [1], and also the editors for inviting this debate. It is a welcome opportunity to clarify some points and expand upon ...

In response to stress signals, the mammalian heart responds by an increase in its size.1 This is largely accomplished by an increase in the size of myocytes (hypertrophy) rather than by increasing their numbers (hyperplasia). At the molecular level, pathological stresses induce multiple changes, including genetic reprogramming—the reexpression of a battery of fetal genes and the downregulation ...

Three factors have been identified that reconstitute nuclear protein import in a permeabilized cell assay: the NLS receptor, p97, and Ran/TC4. Ran/ TC4, in turn, interacts with a number of proteins that are involved in the regulation of GTP hydrolysis or are components of the nuclear pore. Two Ran-binding proteins, RanBP1 and RanBP2, form discrete complexes with p97 as demonstrated by immunoads...

•A conformation-adaptive fluorophore is reversibly modulated in [2]catenanes•The mechanically interlocked structure enables a robust fluorescent molecular switch•Two modulation modes, including wavelength and intensity, can be programmed Developing systems with tunability plays an important role many practical applications such as sensors, photo-electric devices, imaging, display devices. Learn...