Hypoxia and reoxygenation are common characteristics of solid tumors, which lead to oxidative stress and activation of stress-response genes. Previously, we observed that N-myc downstream-regulated gene 1 (NDRG1) was strongly down-regulated after shifting to reoxygenation, but the regulatory mechanism of NDRG1 remained elusive. Here we focused on the regulation of NDRG1 by microRNAs (miRNAs). B...

This paper develops a general equilibrium model of multi-product firms and analyzes their behavior during trade liberalization. Firm productivity in a given product is modeled as a combination of firm-level “ability” and firmproduct-level “expertise”, both of which are stochastic and unknown prior to the firm’s payment of a sunk cost of entry. Higher firm-level ability raises a firm’s productiv...

Results 50 BD patients (median age: 38.30±11.06 years) and 51 controls (median age: 33.88±12.47 years) were recruited. Three types of mutations have found. First: A single nucleotide polymorphism (SNP) c.769-38C>T (rs35191208) in 21 of 50 BD patients and in 15 of 51 controls. Both groups were comparable for the frequency of c.769-38C>T (p>0,05). In all of the cases with c.76938C>T, a second SNP...

*Corresponding author. Mailing address: Mark E. Siddall Associate Curator Division of Invertebrate Zoology American Museum of Natural History Central Park West at 79th Street New York, NY 10024 212 769 5638 fax 212-769-5277 [email protected] CE PT ED Copyright © 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Appl. Environ. Microbiol. doi:10.1...

http://dx.doi.org/10.1016/j.isprsjprs.2015.03.013 0924-2716/ 2015 International Society for Photogrammetry and Remote Sensing, Inc. (ISPRS). Published by Elsevier B.V. All rights reserved. ⇑ Corresponding author at: Roy M. Huffington Department of Earth Sciences, Southern Methodist University, 3225 Daniel Avenue, Room 210, Dallas, TX 75205, USA. Tel.: +1 214 768 2750; fax: +1 214 768 2701. E-ma...

CFTR (cystic fibrosis transmembrane conductance regulator), the protein whose dysfunction causes cystic fibrosis, is a chloride ion channel whose gating is controlled by interactions of MgATP with CFTR's two cytoplasmic nucleotide binding domains, but only after several serines in CFTR's regulatory (R) domain have been phosphorylated by cAMP-dependent protein kinase (PKA). Whereas eight R-domai...

En el sector de la atención emergencias es visible importancia los mecanismos coordinación entre organizaciones, entendidas como formas cooperación mutua que se articulan para atender desastres modernos complejos y con gran potencial impacto adversos. La estos eventos requiere autoridad compartida procesos colaborativos trascienden las tradicionales gestión otros sectores cosa pública ajenos a ...

BACKGROUND Subclinical hypothyroidism (SCH) has been reported to be associated with adverse pregnancy outcomes, however universal screening and treatment is controversial. OBJECTIVES Our objectives were to determine population-specific pregnancy reference values (R1) for serum thyroid-stimulating hormone (TSH) and free thyroxine (FT4) at 14 weeks' gestation, along with the prevalence of SCH a...