نتایج جستجو برای: 962 snps average observed heterozygosity
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The analysis of single nucleotide polymorphisms (SNPs) is increasingly utilized to investigate the genetic causes of complex human diseases. Here we present a high-throughput genotyping platform that uses a one-primer assay to genotype over 10,000 SNPs per individual on a single oligonucleotide array. This approach uses restriction digestion to fractionate the genome, followed by amplification ...
Unigene alignments obtained from cDNA libraries made using multiple individuals are not currently used to estimate population heterozygosity, as they are known to harbor mutations created during library construction. We describe an estimator of population heterozygosity that utilizes only SNPs unlikely to be library construction artifacts.
foroughmand et al. (1) have recently reported association between coronary artery disease (cad) and two well-known single nucleotide polymorphisms (snps) on chromosome 9p21.3 in subjects from south-west iran. we doubt the validity of their findings. genotyping was done using arms-pcr for rs1333049 and rs10757274 in their study. when we first looked at the genotype frequencies, we observed a sub...
calpastatin (cast) is a specific inhibiter of calpains, playing a role in meat tenderization and myogenesis. in the present study the polymorphism of the cast gene ofkhalkhali goat in azerbaijan province in iran was investigated by polymerase chain reaction and restriction fragment length polymorphism technique (pcr-rflp). genomic dna was extracted from whole blood samples collected from 200 kh...
Genotyping was done using ARMS-PCR for rs1333049 and rs10757274 in their study. When we first looked at the genotype frequencies, we observed a substantial excess of heterozygote subjects for both SNPs. Specifically, the relative excess of heterozygosity (REH) (2), a measure for the strength of deviation from Hardy-Weinberg equilibrium (HWE), was approximately 137% for rs1333049 in controls (RE...
Heterozygosity-fitness correlations (HFCs) have been used to understand the complex interactions between inbreeding, genetic diversity and evolution. Although frequently reported for decades, evidence for HFCs was often based on underpowered studies or inappropriate methods, and hence their underlying mechanisms are still under debate. Here, we used 6100 genome-wide single nucleotide polymorphi...
Next-generation sequencing technologies have opened a new era of research in population genetics. Following these opportunities, the use restriction enzyme-based genotyping techniques, such as site-associated DNA (RAD-seq) or double-digest RAD-sequencing (ddRAD-seq), has dramatically increased last decade. From sampling to SNP calling, laboratory and bioinformatic parameters techniques been inv...
Single nucleotide polymorphisms (SNPs) have been increasingly utilized to investigate somatic genetic abnormalities in premalignancy and cancer. LOH is a common alteration observed during cancer development, and SNP assays have been used to identify LOH at specific chromosomal regions. The design of such studies requires consideration of the resolution for detecting LOH throughout the genome an...
In Iraq generally and Kurdistan region specifically, goats are an important resource for meat milk production. It is well known that Myostatin genes (MSTN) have the essential role in growth development due to its crucial involvement muscle growth. The goal of this research was reveal polymorphism MSTN gene different Capra hircus breeds (native, Shami, Meriz Kamori goat) wild mountain goat (Capr...
Proxy measures of genome-wide heterozygosity based on approximately 10 microsatellites have been used to uncover heterozygosity fitness correlations (HFCs) for a wealth of important fitness traits in natural populations. However, effect sizes are typically very small and the underlying mechanisms remain contentious, as a handful of markers usually provides little power to detect inbreeding. We ...
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