Major depressive disorder (MDD) and Parkinson's disease (PD) share symptoms such as tremor. Bupropion, a norepinephrine-dopamine reuptake inhibitor, shows weak dopamine transporter (DAT) occupancy. We report here on a patient with MDD whose hand tremors might have been misdiagnosed as PD by single-photon emission computed tomography (SPECT) under bupropion use. A 66-year-old male patient with M...

UNLABELLED Technetium-99m TRODAT-1 is an analog of cocaine that selectively binds the presynaptic dopamine transporters. The primary purpose of this study was to measure its whole-body biokinetics and radiation dosimetry in healthy human volunteers. The study was conducted within a regulatory framework that required its pharmacological safety to be assessed simultaneously. METHODS The sample ...

Received 2/20/2002; accepted 3/25/2002. For correspondence or reprints contact:Yi-Hsin Weng, M.D., Movement Disorders Unit, First Department of Neurology, Chang Gung Memorial Hospital, 5 Fu-Shin Street, Kweishan, Taoyuan 333, Taiwan, R.O.C. Tel: (886)3-3281200 ext. 8414, Fax: (886)3-3971504 Hydrocephalus is often characterized by gait disturbance, cognitive dysfunction, and/or urinary incontine...

Quantification of regional (99m)Tc-TRODAT-1 binding ratio in the striatum regions in SPECT images is essential for differential diagnosis between Alzheimer's and Parkinson's diseases. Defining the region of the striatum in the SPECT image is the first step toward success in the quantification of the TRODAT-1 binding ratio. However, because SPECT images reveal insufficient information regarding ...

Introduction Cognitive impairments, the main determinants of functional outcomes in schizophrenia, had limited treatment responses and need a better understanding mechanisms. Dysfunctions dopamine system N-methyl-D-aspartate receptor (NMDAR), primary pathophysiologies may impair cognition. Objectives This study explored effects interactions striatal transporter (DAT) plasma NMDAR-related amino ...

Introduction: Misdiagnosis in Parkinson’s disease (PD) can reach 25%. Recently, single-photon emission computer tomography (SPECT), using dopamine transporter (DAT) radioligands, has become useful to help diagnose clinically unclear cases of Parkinsonism (CUCP). Objectives: Study 1 reported the rationale of molecular imaging in CUCP. Study 2 evaluated the role of DAT neuroimaging in CUCP. Study...

Objective(s): To evaluate the role of Tc-99m TRODAT-1 Single Photon Emission Computed Tomography (SPECT) in Parkinson’s Disease (PD) by assessing the correlation of clinical disease severity, disease duration and age at onset of disease with specific uptake ratio of Tc-99m TRODAT-1 in striatum.Methods: The study included 63 patients in age range of 40-72 years with clinical diagnosis of PD and ...