Clinical reports indicate that cardiotoxicity due to donepezil can occur after coadministration with cilostazol. We speculated that the concentration of donepezil in heart tissuemight be increased as a result of interactionwith cilostazol at efflux transporters suchasP-glycoprotein (P-gp, ABCB1) and breast cancer resistance protein (BCRP, ABCG2), which are expressed inmany tissues including the...

69 INTRODUCTION The success of operating a drive-thru facility depends on queues and waiting times experienced by customers. Drivethru facilities are required to provide queuing areas that can hold the expected maximum queue length. Rates of arrivals and service times affect the required queuing areas for drive-thru facilities. Gattis recommended queuing areas for drive-thru facilities located ...

The prevalence of asthma and other atopic disorders continues to increase worldwide. Examination of the epidemiologic patterns has revealed that this rise has occurred primarily in western, industrialised countries and countries transitioning to this lifestyle. While many changes have occurred in human populations over the years, it has been hypothesised that some of the relevant changes that h...

PHILOSOPHY VII 1999 1. Opening WHAT IS THE EPISTEMOLOGICAL STATUS OF OUR KNOWledge of the truths of arithmetic? Are they analytic, the products of pure reason, as Leibniz held? Or are they high-level empirical truths that we know only a posteriori, as some empiricists, particularly Mill, have held? Or was Kant right to say that, although our knowledge that ‘5+7=12’ depends essentially upon intu...

For many years, the conventional wisdom in the field of mental health has been that severe mental illnesses, particularly schizophrenia, inevitably result in progressive deterioration. Professional practice has then understandably focused on managing psychopathology and its symptoms. Research efforts in the 1960s, 1970s and 1980s documented the heterogeneity of outcomes, particularly for indivi...

The amplification of distinct neural stem/progenitor cell subtypes during embryogenesis is essential for the intricate brain structures present in various vertebrate species. For example, in both mammals and birds, proliferative neuronal progenitors transiently appear on the basal side of the ventricular zone of the telencephalon (basal progenitors), where they contribute to the enlargement of ...