We have studied the metabolism of benzo(a)pyrene (BP) by intact mouse hepatoma cells, at nM concentrations of the carcinogen, using an assay in which we directly measure the rate of BP fluorescence disappearance. The rate of BP metabolism is half-maximal, at limiting cell dilution, when the concentration of BP is about 4 nM. This apparent Km for BP metabolism is much lower than those reported p...

The mixed-mode bending (MMB) test for delamination toughness was first introduced in 1988. This simple test is a combination of the standard Mode I (opening) test and a Mode II (sliding) test. This MMB test has become widely used in the United States and around the world for mixed-mode toughness measurements. Because of the widespread use of this test method, it is being considered for standard...

The development of experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis, has been studied in mice that were (i) vitamin D-deficient, (ii) minus the vitamin D receptor, (iii) minus a vitamin D 25-hydroxylase, and (iv) minus the vitamin D 25-hydroxyvitamin D-1α-hydroxylase. EAE development was markedly suppressed in mice lacking the vitamin D receptor and partially suppr...

Micro-optical-electrical-mechanical systems (MOEMS) present a new set of challenges for mixed technology systems on a chip (SoC) designers including the need for mixed-signal multi-domain simulation. We present new modeling techniques for optical and mechanical MEM components and apply these models for improved system-level simulation accuracy of MOEMS switches.

The electronics industry is increasingly focused on the consumer marketplace, which requires low-cost high-volume products to be developed very rapidly. This, combined with advances in deep submicrometer technology have resulted in the ability and the need to put entire systems on a single chip. As more of the system is included on a single chip, it is increasingly likely that the chip will con...

Transplant tolerance induced in adult animals is mediated by alloantigen-specific CD4+CD25+ T cells, yet in many models, proliferation of CD4+ T cells from hosts tolerant to specific-alloantigen in vitro is not impaired. To identify changes that may diagnose tolerance, changes in the patterns of proliferation of CD4+, CD4+CD25+, and CD4+CD25- T cells from DA rats tolerant to Piebald Virol Glaxo...

A mode-dependent embedded-process-zone (EPZ) model has been developed and used to simulate the mixed-mode fracture of plastically deforming adhesive joints. Mode-I and mode-II fracture parameters obtained from previous work have been combined with a mixed-mode failure criterion to provide quantitative predictions of the deformation and fracture of mixed-mode geometries. These numerical calculat...

The petroleum-derived degrading Dietzia cinnamea strain P4 recently had its genome sequenced and annotated. This allowed employing the data on genes that are involved in the degradation of n-alkanes. To examine the physiological behavior of strain P4 in the presence of n-alkanes, the strain was grown under varying conditions of pH and temperature. D. cinnamea P4 was able to grow at pH 7.0-9.0 a...