نتایج جستجو برای: a randomized clinical trail
تعداد نتایج: 13707394 فیلتر نتایج به سال:
Based on preclinical studies demonstrating that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) exerts a potent and cancer cell-specific proapoptotic activity, recombinant TRAIL as well as agonistic anti-TRAIL-R1 and anti-TRAIL-R2 antibodies recently entered clinical trials. Additionally, gene therapy approaches using TRAIL-encoding adenovirus (Ad-TRAIL) are currently being deve...
The tumor necrosis factor (TNF)-related apoptosis-inducing ligand- receptor (TRAIL-R) family has emerged as a key mediator of cell fate and survival. Ligation of TRAIL ligand to TRAIL-R1 or TRAIL-R2 initiates the extrinsic apoptotic pathway characterized by the recruitment of death domains, assembly of the death-inducing signaling complex (DISC), caspase activation and ultimately apoptosis. Con...
Aim: to assess the clinical effectiveness of Giomer varnish in comparison sodium fluoride reducing hypersensitivity. Methodology: Using a Split mouth design, 66 participants were enrolled. Each participant should have at least two sensitive teeth different sides same jaw, with visual analogue scale score or more. Teeth examined by using stimuli: Evaporative, thermal and tactile stimuli. Sides c...
Molecular farming has been considered as a secure and economical approach for production of biopharmaceuticals. Human TNF Related Apoptosis Inducing Ligand (TRAIL) as a promising biopharmaceutical candidate has been produced in different expression hosts. However, little attention has been paid to molecular farming of the TRAIL in spite of numerous advantages of plant expression systems. Theref...
disease is a matter with which each person may face in his life. if caregivers want to provide real and complete health care services, comprehensive attention to the spiritual needs of a patient is indispensibe. since many people obtain spirituality through religion, appropriate religious care can promote spiritual health of patients. this research aimed at examining religious care program and ...
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its agonistic antibodies, which are currently in early clinical trials for treating various malignancies, induce apoptosis through triggering of either TRAIL-R1 or TRAIL-R2. Based on studies using agonistic monoclonal antibodies, we recently proposed that primary chronic lymphocytic leukemic cells seem to signal apoptosis prima...
Here, we provide evidence for a detrimental role of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in neural death in T cell-induced experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Clinical severity and neuronal apoptosis in brainstem motor areas were substantially reduced upon brain-specific blockade of TRAIL after induction of EAE ...
هدف: در این مطالعه به بررسی میزان اثربخشی سولفاسالازین بر روی عوارض روده ای بیماران تحت رادیوتراپی در بیمارستان بوعلی و انستیتو پرتوپزشکی اوین سال 89-88 پرداختیم.روش مطالعه: در این مطالعه که به صورت مداخله ای (interventional) از نوع کارآزمایی بالینی تصادفی دوسوکور (double-blind randomized clinical trial) انجام شده است، 36 بیمار تحت رادیاسیون در بیمارستان بوعلی و انستیتو پرتوپزشکی نوین در سالهای...
مقدمه: این مطالعه به منظور بررسی اثر مچ بند طبی در درمان سندرم کانال کارپ در بیماران مراجعه کننده به بیمارستانهای دانشگاه آزاد اسلامی تهران در سال 1388 انجام شده است. روش مطالعه: این مطالعه به صورت یک بررسی مداخله ای (interventional) از نوع کارآزمایی بالینی تصادفی (randomized clinical trial) انجام شده است. حجم نمونه مورد بررسی شامل 50 بیمار دچار سندرم کانال کارپ مراجعه کننده به بیمارستانهای دا...
هدف: در این مطالعه به بررسی اثر سولفات روی خوراکی در درمان زگیل های متعدد در بیماران مراجعه کننده به کلینیک پوست بیمارستان بوعلی در سالهای 89-1388 پرداختیم. روش مطالعه: این مطالعه یک بررسی مداخله ای (interventional) از نوع کارآزمایی بالینی تصادفی (double blind randomized clinical trial) است که بر روی 30 بیمار مبتلا به زگیل های متعدد مراجعه کننده به کلینیک پوست بیمارستان بوعلی در سالهای 89-1388...
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