A series of 1,3-benzoazole derivatives possessing amide moieties were designed, synthesized and evaluated as inhibitors against human dihydroorotate dehydrogenase (hDHODH). Compounds A11, A14 and A26 exhibited good to excellent activities against hDHODH at the concentration of 10μM. In particular, compound A14 displayed an IC50 value of 0.178μM with 2-fold preference over A771726. The result im...

This brief summary provides an overview of a recent National Academies (NA) report on the topic of cancer risks in populations living near U.S. nuclear power plants and facilities. The initial NA Phase I report describes general issues involved in providing scientifically valid descriptions of these risks, suggests two distinct study designs for further consideration, and proposes additional wo...

Nucleotide residues in E. coli tRNA(Phe) interacting directly with proteins in pre- and posttranslocated ribosomal complexes have been identified by UV-induced cross-linking. In the tRNA(Phe) molecule located in the Ab-site (pretranslocated complex) residues A9, G18, A26 and U59 are cross-linked with proteins S10, L27, S7 and L2, respectively. In tRNA(Phe) located in the Pt-site (posttranslocat...

Vaccinia virus envelope protein A27 has multiple functions and is conserved in the Orthopoxvirus genus of the poxvirus family. A27 protein binds to cell surface heparan sulfate, provides an anchor for A26 protein packaging into mature virions, and is essential for egress of mature virus (MV) from infected cells. Here, we crystallized and determined the structure of a truncated form of A27 conta...

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The evolution of color categorization is investigated using artificial agent population categorization games, by modeling observer types using Farnsworth-Munsell 100 Hue Test performance to capture human processing constraints on color categorization. Homogeneous populations of both normal and dichromat agents are separately examined. Both types of populations produce near-optimal categorizatio...

The evolution of color categorization is investigated using computer simulations of agent population categorization games. Various realistic observer types are implemented based on Farnsworth-Munsell 100 Hue Test human performance data from normal and anomalous trichromats, dichromats, and humans with four retinal photopigments. Results show that (i) a small percentage of realistically modeled ...