The binding sites of antitumor drug doxorubicin (DOX) and its analogue N-(trifluoroacetyl) doxorubicin (FDOX) with tRNA were located, using FTIR, CD, fluorescence spectroscopic methods and molecular modeling. Different binding sites are involved in drug-tRNA adducts with DOX located in the vicinity of A-29, A-31, A-38, C-25, C-27, C-28, G-30 and U-41, while FDOX bindings involved A-23, A-44, C-...

A29-year-old man presented with unilateral dull headache for 3 days, similar to previous headache, but with right hemiparesis; there was no antecedent infection or trauma. MRI showed left striatocapsular infarction (figure 1A), without evidence of cardioembolism or vasculitis. Digital subtraction angiography demonstrated stenosis of the left middle cerebral artery (MCA) trunk (figure 1B). Intra...

We present a new analysis of Robert Grosseteste's account of color in his treatise De iride (On the Rainbow), dating from the early 13th century. The work explores color within the 3D framework set out in Grosseteste's De colore [see J. Opt. Soc. Am. A29, A346 (2012)], but now links the axes of variation to observable properties of rainbows. We combine a modern understanding of the physics of r...

PURPOSE To determine the cytokine response to ocular lysates of peripheral blood mononuclear cells (PBMCs) from patients with birdshot chorioretinopathy (BSCR). METHODS In the PBMCs of 19 patients with BSCR, T cell cytokine production in response to human retina and choroid lysates was analyzed with flow cytometry and compared to the responses against skin lysates. Five patients had active di...

We present new high resolution (100) neutral hydrogen (H i) self-absorption images of the Riegel-Crutcher cloud obtained with the Australia Telescope Compact Array and the Parkes Radio Telescope. The Riegel-Crutcher cloud lies in the direction of the Galactic center at a distance of 125±25 pc. Our observations resolve the very large, nearby sheet of cold hydrogen into a spectacular network of d...