In recent observations of Brownian motion of islands of adsorbed atoms and of vacancies with mean radius R , the cluster diffusion constant Dc varies as R 21 and R. From an analytical continuum description of the cluster’s steplike boundary, we find a single Langevin equation for the motion of the cluster boundary, rather than three special cases. From this we determine Dc and the correlation f...

A51-year-old patient presented with a second episode of transient loss of vision. A persistently patent foramen ovale (PFO) was diagnosed with a transesophageal echocardiogram, and percutaneous closure with an implantable device (PfoStar, Cardia, Inc) was done. The PfoStar is a catheter implantable device consisting of 2 polyvinyl sheets spread by 2 crossed nitinol wires. The axis of the left a...

It has previously been shown that incubation of mammalian cell cytosolic extracts with the protein kinase inhibitor tyrphostin A25 results in enhanced transfer of methyl groups from S-adenosyl-[methyl-3H]methionine to proteins. These findings were interpreted as demonstrating tyrphostin stimulation of a novel type of protein carboxyl methyltransferase. We find here, however, that tyrphostin A25...

from Streptomyces cae@pitoaua(i), has been demon strated to have strong antitumor action not only on solid, ascitic, and leukemic tumors of the mouse, the rat, and the hamster (3, 10, 13, 16, 18), but also on various types of human cancer (14, 17). It was also shown by Perlman and his associates (8) that this antibiotic was highly toxic against the mouse fibroblast strain L cells cultured in vi...

Riboswitches are a class of metabolism control elements mostly found in bacteria. Due to their fundamental importance in bacteria gene regulation, riboswitches have been proposed as antibacterial drug targets. Prequeuosine (preQ1) is the last free precursor in the biosynthetic pathway of queuosine that is crucial for translation efficiency and fidelity. However, the regulation mechanism for the...

We have identified 2'-hydroxyl groups of the U6 phosphate-ribose backbone which are required for reconstitution of splicing activity in U6-depleted yeast extract. To screen the 2'-hydroxyls of yeast U6 at nucleotides 39-88, spanning the conserved central domain, synthetic U6 RNAs were constructed with deoxyribonucleotides incorporated site specifically. Only four individual deoxynucleotide subs...

We consider a linear kinetic transport equation under diffusive scaling that converges to diffusion as the Knudsen number $\varepsilon\rightarrow 0$. In [S. Boscarino, L. Pareschi, and G. Russo, SIAM J. Sci. Comput., 35 (2013), pp. A22--A51; Z. Peng et al., Comput. Phys., 415 (2020), 109485], achieve asymptotic preserving (AP) property unconditional stability in regime with $\varepsilon\ll 1$, ...

The human interleukin-3 (IL-3) receptor is constitutively expressed on certain hematopoietic cells where it mediates proliferation and differentiation, or functional activation. We have recently found that human umbilical vein endothelial cells (HUVECs) also express IL-3 receptors and that the expression is enhanced by stimulation with the monokine tumor necrosis factor a. In this report we sho...